三七总皂苷对肝纤维化小鼠血清中转化生长因子-β1及白介素-1的影响  

Effects of Panax notoginseng Saponins on TGF-β1 and IL-1 in Mice Serum with Liver Fibrosis

作　　者：余万桂[1] 张恒文[1] 贺尚荣[1] 晏年春[1] 

机构地区：[1]长江大学医学院,湖北荆州434000

出　　处：《时珍国医国药》2006年第1期54-55,共2页Lishizhen Medicine and Materia Medica Research

摘　　要：目的观察三七总皂苷对肝纤维化小鼠血清中TGF-β1及IL-1的影响,探讨三七总皂苷抗肝纤维化可能的免疫学机理。方法用CC l4复制小鼠中毒性肝纤维化模型,同时给与三七总皂苷治疗,酶联免疫吸附实验(ELISA法)测定血清中TGF-β1及IL-1的水平,并行肝脏病理组织切片检测。结果三七总皂苷能显著降低肝纤维化小鼠血清中TGF-βl及IL-1的水平,减轻肝纤维化程度。结论三七总皂苷具有抗肝纤维化作用,其机理可能与降低血清中TGβ-p1及IL-1的水平有关。Objective To observe effects of Panax notoginseng saponins（PNS） on TGF-β1 and IL-1 of serum in mice with liver fibrosis, Methods The model of CCl4 induced liver fibrosis was established in mice and they were treated with PNS. Serum level of TGF-β1 and IL-1 were determined and observed tissue pathology. Results It significantly decreased level of TGF-β1 and IL-1 in serum with PNS treatment, and the liver fibrosis was improved. Conclusion PNS has reversal effects on mice with hepatic fibrosis,it may be correlated with drop serum level of TGF-β1 and IL-1.

关 键 词：三七总皂苷 肝纤维化 转化生长因子-Β1 白介素-1 小鼠 

分 类 号：R972.9[医药卫生—药品]