老年人痰浊阻遏证组3种血清黏附分子表达的比较  

Blood Serum Adhesion Molecule Expressions in Old Person with Sputum Stasis Syndrome

作　　者：张茂华[1] 金国健[1] 樊锦秀[1] 朱红[1] 朱慧民[1] 谢英姿[1] 王志敏[1] 王国芬[1] 杨铁伟[1] 万卫昌[1] 

机构地区：[1]上海瑞金医院集团台州市中心医院,浙江台州318000

出　　处：《中医药学刊》2006年第1期72-73,共2页Study Journal of Traditional Chinese Medicine

基　　金：浙江省卫生厅立项课题(200301126)

摘　　要：目的:基于黏附分子在疾病发生、发展中的重要作用,探讨老年人常见中医证候分型中黏附分子的表达,比较痰浊阻遏证与正常对照组之间的差异。方法:采用临床流行调查方法与实验检测相结合,设正常对照组24例,以社区老年人155例为研究对象,经中医辨证分层有痰浊阻遏证组42例。采用酶联免疫吸附(双抗体夹心)法测定血清P-选择素(P-SELECTIN)、细胞间黏附分子-1(sICAM-1)、单核细胞趋化因子蛋白-1(MCP-1)水平,分析各组与对照组之间的差异。结果:①血清细胞间黏附分子(sICAM-1),在正常对照组为(3.148±1.20)ng/mL,在痰浊阻遏证组为(4.30±1.46)ng/mL,明显增高(P<0.01);②血清P-选择素为(11.53±8.58)ng/mL、单核细胞趋化因子蛋白-1(12.42±5.25)ng/mL,与正常对照组比较无显著性差异(P>0.05)。结论:老年人痰浊阻遏证组中sICAM-1血清水平,明显高于正常对照组,探测在炎症反应、动脉粥样硬化的发生与发展中起着重要作用的分子,可能是中医证候分型差别存在的物质基础,寻求中医药诊治的新的切入点。Objective： To study the relationship between some TCM syndromes and some blood serum adhesion molecule expressions,especially for sputum stasis syndrome. Methods： integrated clinic epidemical investigation and lab examination. There were 42 sputum stasis syndrome cases. As the control there were 24 health persons. We have examined the blood serum adhesion molecule lev- els by ELISA, such as P - SELECTIN, sICAM - 1, MCP - 1. Results ： （1）The P - SELECTIN level （ 10.84 ± 5.85） ng/mL was not high- er than the control（ P 〉 0. 05 ）. （2）The sICAM - 1 level（4.30 ± 1.46） la,g/mLwas higher than the control （ P 〈 0. 01 ）. Conclusion： The study shows that there was a link - response expression of blood serum adhesion molecules in TCM syndromes. The levels of sICAM - 1 in sputum stasis syndreme group was higher than the control.

关 键 词：老年人 中医证候 酶联免疫吸附法 P-SELECTIN SICAM-1 MCP-1 

分 类 号：R592[医药卫生—老年医学]