Early metabolism evaluation making traditional Chinese medicine effective and safe therapeutics  

作　　者：刘勇 杨凌 

机构地区：[1]Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, the Chinese Academy of Sciences, Dalian 116023, China

出　　处：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2006年第2期99-106,共8页浙江大学学报（英文版）B辑（生物医学与生物技术）

基　　金：ProjectsupportedbytheNationalBasicResearchProgram(973)ofChina(Nos.2003CCA03400and2003CB716005),andtheLeadingProgramoftheChineseAcademyofSciences(No.KGCXZ-SW-213-04),China

摘　　要：Increasing attention is being paid to the scientific evaluation of traditional Chinese medicine （TCM）. As many TCMs are capable of biotransformation in the gastrointestinal tract, attention to biotransforrnation of TCM in the gastrointestinal tract may lead to discovery of the active components and active mechanisms. In this article, we review reports that host metabolic enzymes and intestinal bacteria may be responsible for the metabolism of TCM. Good understanding of the in vivo course of TCM will help us to know how to conduct metabolism evaluation of TCM by using in vitro human-derived system. This evaluation system will create new views on TCM as effective and safe therapeutic agents.Increasing attention is being paid to the scientific evaluation of traditional Chinese medicine (TCM). As many TCMs are capable of biotransformation in the gastrointestinal tract, attention to biotransformation of TCM in the gastrointestinal tract may lead to discovery of the active components and active mechanisms. In this article, we review reports that host metabolic enzymes and intestinal bacteria may be responsible for the metabolism of TCM. Good understanding of the in vivo course of TCM will help us to know how to conduct metabolism evaluation of TCM by using in vitro human-derived system. This evaluation system will create new views on TCM as effective and safe therapeutic agents.

关 键 词：Traditional Chinese medicine （TCM） METABOLISM Gastrointestinal biotransformation 

分 类 号：R28[医药卫生—中药学]