小儿原发性血小板增多症4例临床及实验室分析  

The clinical and laboratorial analysis of 4 pediatric patients with essential thrombocythemia

作　　者：赵晓明[1] 盛光耀[1] 卢洁[1] 邹湘[1] 徐学聚[1] 

机构地区：[1]郑州大学第一附属医院儿科,450052

出　　处：《中国小儿血液》2005年第6期244-246,共3页China Child Blood

摘　　要：目的探讨小儿原发性血小板增多症(ET)的临床、实验室特征.方法诊断依PVSB标准;行血常规、骨髓细胞形态学、凝血四象、血小板功能等检查.确诊后给予抗凝、活血或马利兰治疗.结果4例患儿中以出血症状诊断2例、血栓症状诊断2例;脾肿大3例;外周血血小板(Plt)724～1028×109/L,易见Plt聚集成堆,可见巨大Plt、畸形Plt;骨髓象巨核细胞明显增多,分类以产板型为主;3例APTT延长,血小板粘附率、聚集功能降低.治疗后症状均缓解,随访至今无恶性转化.结论ET患儿具典型的临床和实验室特征,临床应予以重视,以防误诊.Objective To explore the clinical and laboratorial characteristics with essential thrombocythemia （ET）. Methods Pediatric patients with ET were di of pediatric patients agnosed according to the PVSB standard, and the routine hematological examination, the cellular morphology of bone marrow, the four index of blood coagulation （PT, Fib, APTT, TT）, the platelet function were detected. After diagnosed they were treated with anti - coagulation, blood - Activating or myleran. Results For thc four patients, two were diagnosed by bleeding, others were diagnosed by thrombosis, three cases suffered with splenomegaly; Platelet（Plt） count of peripheral blood were 724 - 1028 × 10^9/L, it was easy to observe the Bernard - Soulier Pit and abnormal Pit. Megakaryocytes in bone marrow were remarkablely increased and main of them were platelet - forming type ; 3 case were detected with longer APTT, lower platelet adhesion and aggregation. After treatment all the symptoms were alleviated, and follow -up to now no one was mall teristics of clinic and laboratory in pediatric they be falsely diagnosed. gnantly transformed. Conclusion There are typical characpatients with ET, which must be paid more attention to lest

关 键 词：血小板增多症 原发性 小儿 临床 实验室 原发性血小板增多症 临床应 实验室分析 小儿 骨髓细胞形态学 实验室特征 出血症状 外周血血小板 血小板粘附率 

分 类 号：R725.5[医药卫生—儿科]