慢性重型乙肝转归预测因素研究  

作　　者：粱雪松[1] 刘雨[1] 宋玉[1] 万谟彬[1] 

机构地区：[1]上海长海医院感染科,200433

出　　处：《中华综合临床医学杂志（北京）》2006年第1期3-5,共3页chinese journal of composite clinical medicine

摘　　要：目的：为了确定慢性重型HBV感染者转归预测因素。方法：本研究对285例慢性重型HBV患者临床资料进行了同顾研究。结果：285例慢性重型HBV患者中98例（34．4％）发生了严重不良后果（死亡或接受肝移植）。存在肝硬化患者613％发生严重不良后果和PT〉30s患者85．7％发生严重不良后果，如果同时存在白蛋白水平低于35班和总胆红素水平〉200μM则严重不良后果发生率升为92．3％。其他同严重不良后果相关因素为最高胆红素水平、PT和肝性脑病和，或腹水形成。结论：慢性重型HBV患者存在这些因素时应早期接受肝脏移植。Clinic feature of 285 patients with severe hepatitis B exacerbation were rebiewed. Ninty eight patients（34.3%） died or underwent liver translation. Preexisiting cirrhosis and a prothrombin time（PT） of 〉30s were assoeiated with adverse outcome in 61.3% and 85.7% of patients,reapectively.The rate of adverse outcome increased to 92.3% when a lbumin levels of ≤35g/L and bilirubin levels of 〉200μM were present.Other factors associated with adverse outcomes ineluded peak bilirubin level,peak PT and the presence of eneephalopathy and/or ascites.Patiens with severe exacerbation of hepatitis B with poor prognostie factors should be eonsidered for early liver transplantation.

关 键 词：重型乙肝 预测因素 慢性 因素研究 转归 严重不良后果 HBV感染者 肝硬化患者 胆红素水平 临床资料 

分 类 号：R512.62[医药卫生—内科学] R512.63[医药卫生—临床医学]