单核细胞单层试验和抗体效价测定预判新生儿溶血病的比较  

Comparison between Monocyte Monolayer Assay and Antibody Titre in Predicting the Hemolytic Disease of the Newborn

作　　者：张嘉敏[1] 陈和平[1] 向东[1] 刘曦[1] 朱自严[1] 刘达庄[1] 

机构地区：[1]上海市血液中心,200051

出　　处：《临床输血与检验》2006年第1期17-19,共3页Journal of Clinical Transfusion and Laboratory Medicine

摘　　要：目的应用单核细胞单层试验和抗体效价测定试验预判新生儿溶血病的效果比较。方法抽取孕妇外周血进行单核细胞单层试验和IgG抗体效价测定,收集新生儿脐血做新生儿溶血病检查,对两种产前检查试验预判新生儿溶血病的各项评价指标进行比较。结果抗体效价测定预判新生儿溶血病的灵敏度为40.0%,特异性为100.0%,准确率为58.6%;单核细胞单层试验预判新生儿溶血病的灵敏度为75.0%,特异性为77.8%,准确率为75.9%。结论单核细胞单层试验预判新生儿溶血病的效果优于效价测定,将两者结合则是较为理想的产前筛查方案。Objective To compare the prediction effect on hemolytic disease of the newborn between monocyte monolayer assay and antibody titre. Methods Peripheral bloods of pregnant women were collected for monocyte monolayer assay and IgG antibody titre. Cord bloods of the newborn were collected for hemolytic disease assay. The evaluation in dexes of these two prenatal assays were compared. Results The sensitivity, specificity and correct prediction percentage of antibody titre were 40.0%, 100.0% and 58.6% respectively. The sensitivity,specificity and correct prediction percentage of monocyte monolayer assay were 75. 0%, 77. 8%and 75.9%respectively. Conclusion The results of monocyte monolayer assay is better than antibody titre in predicting hemolytic disease of the newborn. The combination of these two methods will give an effective solution for prenatal assay.

关 键 词：单核细胞单层试验 抗体效价 产前检查 新生儿溶血病 

分 类 号：R446.11[医药卫生—诊断学] R722.18[医药卫生—临床医学]