咖啡酸锗对小鼠子宫颈癌14号的抑制作用  

The Inhibitory Effect of Germanium Caffeic Acid on the Tumor U_(14)

作　　者：陈晓东[1] 叶连宝[1] 黄桂林[1] 肖纯[1] 

机构地区：[1]江西中医学院,江西南昌330006

出　　处：《中国药业》2006年第1期29-29,共1页China Pharmaceuticals

基　　金：国家自然科学基金资助项目;项目编号:30460148

摘　　要：目的:观察咖啡酸锗对小鼠子宫颈癌14号(U14)的作用。方法:以无菌生理盐水按1∶3稀释,调整细胞数约为2.08×109个/L,于每只小鼠右肢皮下接种0.2mLU14,以咖啡酸锗高、中、低3个剂量连续给药10d,以生理盐水组为模型对照组,计算各剂量组对U14的抑制率。结果:咖啡酸锗高、中剂量对U14有较好的抑制率,低剂量也有一定的抑制作用,且给药前后小鼠体重明显增加。结论:咖啡酸锗对小鼠U14有抑制作用,且毒性很小。Objective： To observe the inhibitory effect of germanium caffeic acid on the tumor U14. Methods： The germanium caffeic acid was administered constantly for 10 d with high, middle, low dose. Results： The group administered high and middle dose had better inhibitory effect and the group with low dose had a little hibitory effect. Moreover, the mice＇s body weight increased evidencely during administering drug. ConcLusion： Germanium caffeic acid has strongly inhibitory effect and low toxicity.

关 键 词：咖啡酸锗 抗肿瘤 子宫颈癌14号 抑制 

分 类 号：R965[医药卫生—药理学] R979.1[医药卫生—药学]