马蔺子素冻干注射剂的制备及其稳定性考察  

Preparation of Irisquinone freeze-drying Injection and its stability

作　　者：张学农[1] 阎雪莹[2] 唐丽华[1] 张强[3] 

机构地区：[1]苏州大学药学院,江苏苏州215123 [2]黑龙江中医药大学,黑龙江哈尔滨150040 [3]北京大学药学院药剂系,北京100083

出　　处：《中成药》2006年第1期15-17,共3页Chinese Traditional Patent Medicine

基　　金：江苏省科技厅社会发展项目资助(编号:BS200522);江苏省高校高新技术产业发展项目资助(编号:JHB05-46)

摘　　要：目的:制备马蔺子素冻干注射剂并对其稳定性进行考察。方法:应用化学动力学原理考察马蔺子素降解规律和影响因素,并采用经典恒温法考察马蔺子素冻干注射剂的稳定性。结果:马蔺子素具有较高的油水分配系数,且水溶液易受pH催化降解,对热不稳定,马蔺子素-羟丙基-β-环糊精包合物冻干注射剂可明显提高其稳定性。结论:马蔺子素包合物冻干注射剂具有良好的稳定性。AIM： To prepare the irisquinone freeze-drying injection and investigate its stability. METHODS： The degradation pattern of irisquinone and its effects were measured. At the same time, the stability of freezedrying injection by classic thermostatical test. RESULTS： Irisquinone solution was unstable to heat and its content decreased remarkably in acid and alkaline solutions. The result showed that oil/water partition coeffecient of irisquinone was very large. The irisquinone-hydropropyll-β-cyclodextrin inclusion complex freeze-drying injection was very effective to enhance the drug stability. CONCLUSION： Irisquinone inclusion complex injection has character of good stability.

关 键 词：马蔺子素 注射剂 冷冻干燥 稳定性 

分 类 号：R944.1[医药卫生—药剂学]