复方“小续命汤”有效成分组对试验性衰老大鼠的作用  

Effect of the group of effective components of Chinese medical prescription-Xiaoxuming Decoction on aging rats

作　　者：王月华[1] 杜冠华[1] 

机构地区：[1]中国医学科学院中国协和医科大学药物研究所,北京100050

出　　处：《中成药》2006年第1期67-71,共5页Chinese Traditional Patent Medicine

基　　金：国家自然科学基金项目:中药复方成分高通量筛选研究(NO.30171148);国家高技术研究发展计划(863计划)课题:创新药物筛选技术平台的研究及应用(2004AA2Z3782)

摘　　要：目的:建立大鼠衰老模型,观察中药复方“小续命汤”有效成分组(GEC)对衰老大鼠的影响。方法:应用D-半乳糖加鱼藤酮建立衰老模型;采用Morris水迷宫法检测大鼠学习记忆能力;并测定大鼠脑中谷胱甘肽(GSH)、丙二醛(MDA)、超氧化物歧化酶(SOD)、乙酰胆碱酯酶(AchE)及胆碱乙酰转移酶(ChAGT)活性。结果:D-半乳糖可引起拟衰老效应,学习记忆能力下降,脑内GSH含量减少、SOD活性降低、MDA含量升高,但对AchE、ChAT无影响。GEC可改善D-半乳糖诱导的衰老大鼠的学习记忆能力下降及某些生化功能改变。结论:提示中药复方“小续命汤”GEC可改善D-半乳糖引起的衰老效应,其作用机制可能与抗氧化有关。AIM： To establish the model of aging rats and observe the effect of the group of effective components of Xiaoxuming Decoction （XXM） on aging rats. METHODS ： D-galactose and rotenone were used to establish aging animal model. The ability of learning and memory were measured by using Morris water maze test. Then, the content of GSH and MDA, the activity of SOD, the activity of AchE and ChAT in rats brain were measured. RESULTS： D-galactose could induce aging like indicators in rats：decrease the content of GSH and the activity of SOD,and increase the content of MDA,but have no effect on AchE and CHAT. It showed that GEC could improve the ability of learning and memory and ameliorate biochemistry function in rats with aging induced by D-galactose. CONCLUSION： These results suggest that GEC of XXM could improve the responses of aging rats and these effects may be related to its ability of antioxidation.

关 键 词：中药复方 有效成分组 D-半乳糖 鱼藤酮 衰老 

分 类 号：R285.5[医药卫生—中药学]