山苦茶利胆作用活性部位的筛选  

Screening of choleretic effect of active fraction in Mallotus furetianus.

作　　者：王九辉[1] 李佩琼[1] 林莲波[1] 符小文[1] 刘军保[1] 

机构地区：[1]海南医学院药学系,海南海口571101

出　　处：《中国热带医学》2006年第1期23-24,66,共3页China Tropical Medicine

基　　金：国家自然科学基金资助项目(30060088)

摘　　要：目的筛选山苦茶利胆作用的活性部位。方法将豚鼠离体胆囊肌条置于恒温浴槽,分别加入山苦茶不同部位并比较其对肌条张力的影响,以及采用胆总管插管引流胆汁方法,观察各部位对大鼠胆汁分泌的作用。结果山苦茶部位B和D对胆囊肌条具有剂量依赖的的收缩作用,并显著促进大鼠胆汁分泌。结论山苦茶B和D部位具有显著的利胆作用。Objective To evaluated and compare the choleretic activity of 4 different fraction isolated from Mallotus furetianus. Methods The effect of different fraction on isometric tension of Guinea pig gallbladder strips mounted in organ baths containing 20ml Krebs solution at 37~C, and the effect on bile secretion of anesthetized mice were determined. Results Fraction B and D showed a concentration- dependent contractile effect on Guinea pig gallbladder strips, and induced a marked increase in bile secretion. Conclusion B and D fraction from Mallotus furetianus show remarkable choleretic effect.

关 键 词：山苦茶汀 利胆作用 活性部位 

分 类 号：R282.7[医药卫生—中药学]