国内首例人感染高致病性禽流感病例流行病学调查  

Epidemiologic survey of the first patient infected with highly pathogenic human avian influenza in China.

作　　者：邓婷[1] 吴铁钢[1] 

机构地区：[1]长沙市雨花区疾病预防控制中心,湖南长沙410011

出　　处：《中国热带医学》2006年第1期47-48,88,共3页China Tropical Medicine

摘　　要：目的了解国内首例人禽流感病例的流行病学特征,以预防高致病性禽流感病毒在人间传播。方法采用病例流行病学调查方法,在实验室对病原体和患者急性期、恢复期双份血清进行检测,同时对与患者密切接触者进行严密的医学观察。结果患者家中于10月6日出现家禽大批死亡,10月10日发病,H5、H7流感病毒核酸、M5流感病毒HA抗原、流感病毒A、B抗原和RSV病毒抗原检查皆为阴性。急性期和恢复期双份血清H5特异性抗体呈4倍以上增高,与患者密切接触者中均未发现异常临床表现。结论经卫生部和WHO专家组鉴定为人感染高致病性禽流感H5N1确诊病例。Objective To understand the epidemiologieal characteristic of the fast patient infected with avian influenza and prevent the highly pathogenic avian influenza virus from spreading among humans. Methods Epidemiologic survey was carried out, laboratory detection of pathogen and detection of double sera from the patient at acute and convalescence phases of avian influenza were conducted. Meanwhile strict observation on those closely contacted with the patient was also made. Results A lot of fowls died in the patient＇ s house on October 6 and the patient fell ill in the same day. The specific antibody H5 of double sera showed a four- fold increase at acute and convalescence phases. No abnormal manifestations were observed among those closely contacted with the patient during strict medical observation, Conclusion The patient was confirmed to be infected with highly pathogenic human avian influenza H5N1 virus as ascertained by expert group of Ministry of Health and WHO.

关 键 词：人禽流感 流行病学 临床表现 

分 类 号：R511[医药卫生—内科学]