不饱和聚磷酸酯的合成及释药性能  

Synthesis and Drug Release Property of Unsaturated Polyphosphoester

作　　者：包瑞[1] 刘承美[1] 邱进俊[1] 许燕[1] 

机构地区：[1]华中科技大学化学系,武汉430074

出　　处：《应用化学》2006年第1期79-83,共5页Chinese Journal of Applied Chemistry

基　　金：国家自然科学基金(20374022)和华中科技大学医工医理交叉基金资助项目

摘　　要：以富马酸、1,2-丙二醇和三氯氧磷为起始原料,采用缩聚法合成了主链重复结构单元中含富马酸酯的不饱和聚磷酸酯(UPPE),采用FT-IR及NMR(1H,13C,31P)对聚合物结构进行表征。在pH=7．4磷酸盐缓冲溶液中,研究了不同含药量及不同UPPE与NVP(N-乙烯基吡咯烷酮)质量比所组成的交联体系对环丙沙星药物的释放性能。结果表明,UPPE与NVP质量比一定时,含药量较小的体系药物释放速度较快;环丙沙星含量一定时,NVP含量较高的体系药物释放速度较快。Unsaturated polyphosphoester（UPPE） containing fumarate segment in the repeat units was synthesized via condensation polymerization reaction with fumaric acid, 1,2-propylene glycol and phosphorous oxychloride as the raw materials. The structure of the polymer was characterized by FT-IR and NMR （ ^1 H, ^13 C, ^31P）. In vitro drug releases of the crosslinking systems of UPPE/NVP with different contents of ciprofloxacin and different mass ratios of UPPE to NVP were studied in phosphate buffer solution （ pH = 7.4） at 37 ℃. The results indicate that a system with a less content of ciprofloxacin releases drug more rapidly when the mass ratio of UPPE to NVP is kept constantly, and a system With a higher mass ratio of NVP to UPPE releases drug more rapidly when the content of ciprofloxacin is kept constantly.

关 键 词：不饱和聚磷酸酯(UPPE) 富马酸二(丙二醇)酯 生物材料 药物缓释 环丙沙星 

分 类 号：O633.1[理学—高分子化学]