罗格列酮对内毒素血症大鼠肺内炎症反应的影响  

Effects of rosiglitazone on pulmonary inflammatory response in endotoxemic rats

作　　者：刘东[1] 曾邦雄[1] 张世范[1] 耿智隆[1] 张诗海[1] 

机构地区：[1]兰州军区兰州总医院麻醉科,兰州730050

出　　处：《中华急诊医学杂志》2006年第1期38-40,共3页Chinese Journal of Emergency Medicine

基　　金：解放军全军医学科学技术研究"十五"计划指令性课题项目(01-L003)

摘　　要：目的探讨PPARγ激动剂罗格列酮(ROSI)对内毒素感染大鼠肺脏炎症反应的影响。方法24只雄性Wistar大鼠,随机分为对照组、ROSI组、内毒素(LPS)组和ROSI处理组(ROSI+LPS),每组6只。注射LPS或生理盐水,4h后测定肺组织髓过氧化物酶(MPO)活性、肿瘤坏死因子α(TNFα)和中性粒细胞趋化因子1(CINC1)浓度以及核因子κB(NFκB)的活性。结果与LPS组比较,ROSI+LPS组MPO活性、TNFα和CINC1浓度、NFκB活性均降低(P<0.01)。结论ROSI能减轻内毒素血症所致的肺脏炎症反应,其机制与抑制NFκB激活有关。Objective To investigate the effects of rosiglitazone, an agonist of peroxisome proliferator-αctivated receptor γ （PPARγ）, on acute lung inflammation in endotoxemic rats. Methods Twenty-four male Wistar rats were randomly divided into four groups （n = 6） ： control group, rosiglitazone （ROSI, 0.3 mg/kg i.v. ） group, endotoxin （LPS, 6 mg/kg i.v. ） group and ROSI （0,3 mg/kg i.v. ） ＋ LPS （6 mg/kg i.v. ） group. Four hours after LPS or saline injection, myeloperoxidase （MPO） activity, tumor necrosis factor-α （TNF-α） and eytokine-induced neutrophil chemoattractant-1 （CINC-1） concentrations, and nuclear factor kB （NF-kB） activation were measured in lung tissues. Results Compared with the LPS group, MPO activity, TNF-α and CINC-1 concentrations, and NF-kB activity in the lung tissues were significantly attenuated in the ROS1 ＋ LPS group （P 〈 0.01 ）. Conclusion Rosiglitazone could reduce pulmonary inflammation caused by endotoxemia. The anti-inflammatory effect of rosiglitazone may be connected with the inhibition of NF-kB activation.

关 键 词：过氧化物酶体增殖物激话受体 内毒素 核因子-KB 细胞因子 

分 类 号：R965[医药卫生—药理学]