3-甲基-4-硝基亚胺基全氢化-1,3,5-二嗪的合成  

Synthesis of 3-methyl-4-nitroiminoperhydro-1,3,5-oxadiazine

作　　者：杨浩[1] 吴公信[1] 张振明[1] 高山[1] 冯溶[1] 梁敏[1] 孙克[1] 

机构地区：[1]沈阳化工研究院,辽宁沈阳110021

出　　处：《农药》2006年第1期24-25,37,共3页Agrochemicals

摘　　要：3-甲基-4-硝基亚胺基全氢化-1,3,5-二嗪是合成第二代烟碱类杀虫剂噻虫嗪的重要中间体。介绍并评价了文献中所报道的合成3-甲基-4-硝基亚胺基全氢化-1,3,5-二嗪的方法。以硝基胍为起始原料成功的合成了3-甲基-4-硝基亚胺基全氢化-1,3,5-二嗪,总收率为68.2%。3-Methyl-4-nitroiminoperhydro-1,3,5-oxadiazine is an important intermediate in the synthesis of the second generation nicotinamide insecticide thiamethoxam. Synthesis methods of 3-methyl-4-nitroiminoperhydro- 1,3, 5-oxadiazine previously reported in the literature are presented and evaluated. We concluded that nitro guanidine is the most successful starting reagent for 3-methyl-4-nitroiminoperhydro-1,3,5-oxadiazine synthesis, providing a total yield of 68.2%.

关 键 词：3-甲基-4-硝基亚胺基全氢化-1 3 5-噁二嗪 噻虫嗪 合成 

分 类 号：TQ453[化学工程—农药化工]