红丝线草对哇巴因所致豚鼠心律失常及LD_(100)的影响  

The Effeets of HONGSIXIAN(HSX) on Ouabain Induced Arrhythmia and LD_(100) in Guinea—pigs

作　　者：杨美玲[1] 杨延秀[1] 黄小彦[1] 胡燕[2] 陈嘉文[2] 王建华[2] 

机构地区：[1]暨南大学医学院药理学教研室 [2]广州中医学院脾胃研究室

出　　处：《暨南大学学报（自然科学与医学版）》1989年第4期7-11,共5页Journal of Jinan University(Natural Science & Medicine Edition)

摘　　要：本研究主要探讨红丝线草的醇提水转溶物(简称01—w)对哇巴因致豚鼠心律失常和LD_(100)的影响。给药组采用三种不同浓度的01—w并分别与0.0125％的哇巴因同速(0.034ml/min)经豚鼠双侧颈外静脉灌注,对照组单用哇巴因,其浓度及灌注速度同给药组。实验结果表明:0.2g(生药)/ml组能显著提高哇巴因致豚鼠心律失常和LD_(10)的剂量(P<0.01),其它剂量组虽略能提高哇巴因致豚鼠心律失常及LD_(100)的剂量,但无统计学显著性。关于ol—w对抗强心甙毒性作用的机制正在深入研究中,可能与它的心肌保护作用有关。This paper described the effects of Alcohol extraot of water soluble HSX(ol-w) on ouabain induced arrhythmia and LD_(100) in guinea-pigs. To the administration group: Three doses of ol-w (0.2g/ml, 0.3g/ml, 0.4g/ml) were infused together with 0.0125％ ouabain into vein jugular superficial of guinea-pigs. To the control group: 0.0125％ ouabain was used only for the infusion of vein jugular superficial of the guinea-pigs. The result showed that 0.2g/ml ol-w could increase tremendously the doses of ouabain to produce arrhythmia and LD_(100) (P<0.01), while 0.3g/ml & 0.4g/ml group could inc rease only slightly the doses of cardiotoxicity of ouabain in guinea-pigs(P>0.05), bu insignificantly. The mechanism of ol-w action is under studying and its anticardiotoxicity may be related to its cardiac protecting property.

关 键 词：红丝线带 哇巴因 豚鼠 心律 

分 类 号：R961[医药卫生—药理学]