地克珠利、氨丙啉与左旋咪唑联合使用对Eimeria tenella的效力试验  

ANTICOCCIDIAL EFFICACY OF DICLAZURIL COMBINED WITH AMPROLIUM AND LEVAMISOLE AGAINST Eimeria tenella

作　　者：聂奎[1] 颜焰[2] 高俊伟[3] 廖申权[4] 刘应良[1] 

机构地区：[1]西南农业大学动物科技学院,北碚400716 [2]新疆农业大学动物医学院,乌鲁木齐830052 [3]华中农业大学动科学院,武汉430070 [4]华南农业大学兽医学院,广州510642

出　　处：《中国兽医寄生虫病》2006年第1期1-4,共4页Chinese Journal of Veterinary Parasitology

摘　　要：目的研究地克珠利与氨丙啉、左旋咪唑的联合抗球虫效果。方法应用均匀设计法对地克珠利、氨丙啉和左旋咪唑的各6个不同剂量进行优化配伍。试验设立6个药物试验组，并设药物对照组、感染不给药组和不感染不给药组．除不感染不给药组外，其余全部试验鸡每只接种E．tenella孢子化卵囊1×10^5个，以抗球虫指数（ACI）判定药物的疗效。结果地克珠利5mg／kg＋氨丙啉240mg／kg＋左旋咪唑1．5mg／kg组的雏鸡存活率为100％，相对增重率97．5％，病变值15．5，其ACI 181．97；而地克珠利2mg／kg组的ACI仅为79．35：其余各组ACI均在150-170之间。结论本试验中以地克珠利5mg／kg＋氨丙啉240mg／kg＋左旋咪唑1．5mg/kg为最佳抗球虫药物组．The efficacy of cmbined Diclazuril with Amprolium and Levamisole against Eimeria tenella was conducted out in this trial. The dosages of Diclzuril, Amprolium and Levamisole were designed as 6 groups by even design. Each bird was infected with 1×10^5 sporulated oocysts of E. tenella at the age of 15 days and the birds of test groups were fed with drugs 2 days prior to infection. Anticoccidial efficacy was evaluated by anticoccidial index （ACI）, weight gain, oocysts per gram feces, lesion scores and mortality. The result showed that the most effective combination was 5 mg/kg Diclazuril, 240 mg/kg Amprolium and 1.5 mg/kg Levamisole, which its ACI,lesion score and chicken survival rate was 181.97,15.5 and 100% respectively; The single Diclzuril （2 mg/kg） was ineffective, for its ACI, lesion score and chicken survival rate was 79.35,34 and 65 % respectively. It suggested that Diclazuril combinating with Amprolium and Levamisole properly could enhance the efficacy.

关 键 词：地克珠利 氨丙啉 左旋咪唑 联合用药 EIMERIA tenella 疗效试验 

分 类 号：S859.79[农业科学—临床兽医学]