抗精神病药对血清催乳素及子宫内膜的影响  

Effect of Antipsychotics on Plasma Levels of Prolactin and Endometrium

作　　者：张震[1] 曹兆霞 吕为农 吴艳春 包和华 马震祥 

机构地区：[1]中国江苏省镇江市第四人民医院,212001 [2]不详

出　　处：《中国健康心理学杂志》2006年第1期49-50,共2页China Journal of Health Psychology

摘　　要：目的探讨氯丙嗪和思瑞康对血清催乳素及子宫内膜的影响及意义。方法对52例女性初发精神分裂症患者在两种药物治疗前、治疗后2周、4周分别检测血清催乳素水平并作B超探测子宫内膜厚度,比较两组结果的差异。结果氯丙嗪组在用药后2周、4周血清催乳素水平逐渐升高且子宫内膜明显增厚,具有显著性差异(P<0.05);与思瑞康相比,疗后2周、4周分别也具有显著性差异(P<0.05)。结论非高度选择性D2受体的新型抗精神病药优于传统抗精神病药,具有良好的服药依从性。Objective To investigate effects of chlorpromazine and serognel on the plasma levels of prolatin （PRL） and the endometrium thick. Methods Fifty-two patients with first-episode schizophrenia were tested plasma levels of PRL, and made B-ultrasonic wave for endometrium thick, before treatment and after 2, 4-week with two kinds of drugs respectively. Results There were significantly differences of plasma PRL and endometrium thick after 2, 4-week treatment between two groups （P〈0. 05） ; in chlorpromazine group, there were significant increase of plasma PRL after 2, 4-week treatment （P〈0. 05）, no significant defference in serognel group （P〉0. 05）. Conclusion Atypical antipsyehotics were superior to typical ones on compliance.

关 键 词：氯丙嗪 思瑞康 催乳素 子宫内膜 

分 类 号：R711.52[医药卫生—妇产科学] R749.3[医药卫生—临床医学]