线粒体三磷酸腺苷敏感性钾通道与心肌预适应  

Mitochondrial ATP-Sensitive K+ Channels and Myocardial Preconditioning

作　　者：钟标[1] 钟焕清[1] 陈海生[1] 

机构地区：[1]广东省高州市人民医院心外科,广东高州525200

出　　处：《医学综述》2006年第2期100-101,共2页Medical Recapitulate

摘　　要：近年来大量的研究提示,应用钾通道开放剂(PCOs)与缺血预适应(IPC)同样具有明显的抗心肌缺血再灌注损伤的作用,而线粒体三磷酸腺苷敏感性钾通道(mitoKATP)在其中起着重要的作用,其机制尚未明了,可能与以下三方面有关:减少线粒体Ca2+超载,调节线粒体容量与能量代谢,调节自由基的生成。Recently, many researches indicated that potassium channel openers（ PCOs）protect the heart against ischemia-reperfusion injury as remarkably as ischemic precoeditioning（IPC）does. And mitochondrial ATP-sensitive K^＋ ehannel（mitoKATP）plays an important role in the protection. The protective mechanism of mitoKATP is unclear, However, it has a close relation to decreasing in mitochondrial Ca^2＋ uptake, regulating the releases of reactive oxygen species, regulating mitochondrial volume and energetic metabolism are believed to he involved.

关 键 词：缺血再灌注损伤 线粒体 ATP敏感性钾通道 心肌保护 预适应 

分 类 号：R654.2[医药卫生—外科学]