高果糖餐诱导实验性胰岛素抵抗综合征大鼠模型  

High-fructose Diet Inducing Experimental Insulin Resistance Syndrome in Making Rat Models

作　　者：程海波[1] 司晓晨[1] 尚文斌[1] 卞慧敏[2] 

机构地区：[1]南京中医药大学第一临床医学院,江苏南京210029 [2]南京中医药大学植物药深加工工程中心,江苏南京210029

出　　处：《南京中医药大学学报》2006年第1期31-34,共4页Journal of Nanjing University of Traditional Chinese Medicine

基　　金：江苏省教育厅自然科学基金(99KJB360001);江苏省中医药局资助项目(9924)

摘　　要：目的建立高果糖餐诱导的胰岛素抵抗综合征大鼠模型。方法Wistar雄性大鼠给予饮用10%果糖水喂养共6周,以正常血糖-高血浆胰岛素钳夹技术评定大鼠的胰岛素敏感性,测定各组大鼠葡萄糖耐量、血清游离脂肪酸、甘油三酯、血浆胰岛素、胰岛素敏感性指数、血压及体质量。结果与空白组大鼠比较,模型大鼠的体质量无明显增加,但血压明显增高,葡萄糖耐量减低,血清甘油三酯、游离脂肪酸、血浆胰岛素含量均显著升高,胰岛素敏感性指数、葡萄糖输注率(GIR)、葡萄糖摄取率明显下降。结论高果糖餐喂养Wistar雄性大鼠可以造成胰岛素抵抗综合征大鼠模型。OBJECTIVE To establish rat models with insulin resistance syndrome induced by high- fructose diet. METHOD Wistar male rats were fed with 10% fructose liquid for six weeks. Routine clamping technique of blood sugar - high blood plasma insulin was used to evaluate the rats＇ insulin sensitivity and determine glucose tolerance, serum free fatty acid, triglyceride, plasma insulin, insulin sensitivity indexes, blood pressure and body weight. RESULT Compared with the blank group, in the model group the body weight did not increase markedly, but blood pressure increased greatly, glucose tolerance decreased, serum triglyceride, free fatty acid and plasma insulin content rose significantly, insulin sensitivity indexes, glucose infusion rate and glucose ingestion rate dropped markedly. CONCLUSION It is possible to use high-fructose diet to create rat models with insulin resistance syndrome.

关 键 词：胰岛素抵抗综合征 大鼠模型 高果糖餐 胰岛素抵抗 

分 类 号：R587[医药卫生—内分泌]