复方丹参缓释片中水溶性成分体外释放度研究  

Study on the water-soluble composition release of compound Danshen sustained-release tablet

作　　者：朱盛山[1] 袁旭江[1] 李苑新[1] 

机构地区：[1]广东药学院中药开发研究所,广东广州510224

出　　处：《中国中药杂志》2006年第1期37-40,共4页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金项目(30472198);国家中医药管理局项目(04-05ZP50);广东省自然科学基金项目(04105450)

摘　　要：目的:研究复方丹参缓释片溶出度,探索中药复方缓释制剂的评价方法。方法:采用转篮法和高效液相色谱指纹图谱评价。结果:通过对6个时间点进行取样测定,丹参缓释片水溶性成分能够比较均衡的释放出来,具有一致的均衡释放行为,从丹酚酸B的释放行为来看较符合Higuchi方程释放,以人参皂苷Rg1的释放行为来看较符合零级释放。结论:丹参缓释片水溶性成分溶出度具有良好的缓释行为。方法快速、简便稳定,可用于评价复方丹参缓释片水溶性成分体外释放度。Objective： To study on the release of compound Danshen sustalned-release tablet and the evaluate method of Chinese material medica compound sustained-release preparation. Method： Rotating basket method and HPLC were employed. Result： Through the determination of 6 time-point samples, the water-soluble compositions of compound Danshen sustained-release tablet had a Well-balanced release behavior with a zero-grade release model or Higuchi release model. Conclusion： Compound Danshen sustained-release tablet had a zero-grade release model. The method was rapid and stable and could be applied to evaluate the water-soluble composition release of compound Danshen sustained-release Tablet.

关 键 词：复方丹参缓释片 体外释放度 HPLC 

分 类 号：R286[医药卫生—中药学]