过量碘对大鼠血清TC和TG水平的影响  

Effect of excessive iodine exposure on the serum TC and TG level in rats

作　　者：杨雪锋[1] 庞红[1] 徐健[1] 郭怀兰[1] 侯晓晖[1] 陈骁熠[1] 孙秀发[1] 

机构地区：[1]华中科技大学同济医学院公共卫生学院营养与食品卫生学系,武汉430030

出　　处：《卫生研究》2006年第1期108-110,共3页Journal of Hygiene Research

基　　金：国家自然科学基金重点项目(No.30230330)

摘　　要：目的观察长期过量碘摄入对大鼠血清TC和TG水平的影响,并对其在评价过量碘危害中的意义进行探讨。方法将60只Wistar大鼠按体重随机分为6组:A组正常对照组,给予去离子水;B～F组为过量碘组,碘剂量分别为1800、3600、7200、14000和28000μgL,喂饲以KIO3配制成不同浓度的高碘水。3个月后,观察甲状腺病理变化,测定尿碘水平、血清甲状腺激素水平和血脂水平。结果各过量碘组大鼠甲状腺未出现明显病理组织学改变。各过量碘组大鼠的尿碘水平随着碘剂量的升高显著升高。TT4水平呈剂量依赖性的降低,在7200μgL组开始与对照组相比有显著性差异。TT3水平各组间无显著性差异。血清TC水平与碘剂量呈显著正相关,在3600μgL组就显著高于正常对照组。TG水平虽有升高,但各组间无显著性差异。血脂与甲状腺激素和尿碘水平的相关性分析表明,血清TC水平与尿碘水平呈显著正相关,与TT4水平呈显著负相关。结论长期过量碘摄入会升高大鼠血脂水平,血脂可以与尿碘、血甲状腺激素一起作为监测过量碘摄入的生物标志物。Objective To study effect of excessive iodine exposure on the serum TC and TG level in rats. Methods According to body weight, 60 Wistar rats were divided into 6 groups and given drinking water including different doses of iodine. The iodine concentrations were 0（control）, 1800, 3600, 7200, 14000 and 28000μg/L, respectively. Three months later, related indices were determined. Results In excessive iodine groups, no obvious changes of thyroid morphology was observed. Urinary iodine level increased dose-dependently. Excessive iodine intake resulted in a significant reduce of serum TT4 level and an obvious inerease of serum TC level in a dose-dependent manner. The positive correlation was observed between serum TC and urinary iodine. There was the negative correlation between serum TC and serum TT4 .Conclusion Excessive-iodine exposure resulted in an increase in serum TC level. And serum lipids, together with urinary iodine and serum thyroid hormones, could be used as biomarkers for excessive iodine exposure.

关 键 词：过量碘 血脂 甲状腺激素 尿碘 生物标志物 

分 类 号：Q573[生物学—生物化学] R581.1[医药卫生—内分泌]