急性肺血栓栓塞症患者凝血纤溶标志物的临床价值  

Evaluation of Coagulation and Fibrinolysis in Patients WithAcute Pulmonary Thromboembolism

作　　者：杨冀萍[1] 刘怀军[1] 阎锡新[2] 张聪敏[2] 吴雅丽[2] 关继涛[2] 

机构地区：[1]河北医科大学第二医院影像科,河北省石家庄市050000 [2]河北医科大学第二医院呼吸科,河北省石家庄市050000

出　　处：《中国循环杂志》2005年第6期451-453,共3页Chinese Circulation Journal

摘　　要：目的:探讨急性肺血栓栓塞症(PTE)患者溶栓治疗前后凝血纤溶标志物变化及临床意义。方法:采用酶联免疫吸附法检测36例急性PTE患者[其中大面积PTE(大面积PTE组)15例,次大面积PTE(次大面积PTE组)21例]及20例健康者为对照组的血浆凝血烷(TX)B2、6酮前列腺素F1α(6KetoPGF1α)和D二聚体,并比较PTE患者溶栓治疗前后各项指标的变化。结果:急性PTE患者大面积PTE组及次大面积PTE组血浆D二聚体、TXB2、TXB2/6KetoPGF1α值明显高于对照组,其中大面积PTE组血浆D二聚体、TXB2、TXB2/6KetoPGF1α值明显高于次大面积PTE组,均有极显著性差异(P<0.01)。急性PTE患者经溶栓和抗凝治疗后1周血浆D二聚体、TXB2及TXB2/6KetoPGF1α值较治疗前下降,有极显著性差异(P<0.01);而血浆6KetoPGF1α治疗后1周较治疗前有上升趋势。结论:检测凝血纤溶标志物对急性PTE患者诊断和疗效评估有临床意义。Objective ： To assess the change of coagulation and fibrinolysis and its significance in patients with pulmonary thromboembolism（PTE）. Methods： The plasma thromboxane （TX）B2 ,6-Keto-PGF1α and D-dimer were detected in 36 patients with PTE （15 massive and 21 submassive） and their changes more compared. Results： In PTE group, the levels of TXB2, D-dimer and T/K were significantly higher than in the control group （P〈 0. 01 ）, and even higher in the massive group than in the submassive group （P 〈0.01 ）. But the level of 6-Keto-PGF1α in patients with PTE was significantly lower than the control group（P 〈 0. 01 ）. The level of 6-Keto-PGF1α significantly increased after therapy （ P 〈 0. 01 ）, and other factors significantly decreased after therapy （ P 〈 O. 01 ）. Conclusions： The assessment of coagulation and fibrinolysis is helpful.

关 键 词：肺血栓栓塞症 6-酮-前列腺素F1Α 凝血噁烷B2 

分 类 号：R541[医药卫生—心血管疾病]