TNF-α、HGF在急性胰腺炎中的变化及意义  

Changes and clinical significance of tumor necrosis factor-α and hepatocyte growth factor in acute pancreatitis

作　　者：龚建明[1] 余志彬[1] 杨朝晖[1] 

机构地区：[1]天府矿务局总医院,重庆北碚400704

出　　处：《现代医药卫生》2006年第1期15-16,共2页Journal of Modern Medicine & Health

摘　　要：目的:探讨急性胰腺炎(AP)患者血清肿瘤坏死因子!(TNF-!)、肝细胞生长因子(HGF)的水平变化,分析其变化规律及对病情判断的价值。方法:应用酶联免疫吸附法(ELISA)测定39例AP及20例对照组血清TNF-!和HGF水平。结果:AP患者血清TNF-!和HGF水平明显高于对照组(P<0.01),在发病第一天,重症AP患者TNF-!水平明显高于轻症AP患者,而HGF则轻症AP患者较高,差异有显著性(P<0.01)。结论:TNF-!和HGF参与了AP的发生、发展过程,可作为AP早期诊断的参考指标。Objective：To investigate the changes of serum levels of tumor necrosis factor-α （TNF-α） and hepatocyte growth factor （HGF） in patients with acute pancreatitis（AP）,and analyse the rules of change and the values in judging the patient＇s condition.Methods： The serum levels of TNF-α and HGF in 39 patients with AP and 20 normal control subjects were measured by ELISA.Results：The serum levies of TNF-α and HGF in AP patients were significantly higher than those in normal control subjects （P〈0.01）.In the first day after on- set, the serum level of TNF-α in severe AP patients was significantly higher than that in mild AP patients,however the serum level of HGF in mild AP patients was higher,the difference was significant （P〈0.01）.Conclusion：TNF-α and HGF participate in the process of occurfence and development of AP,which can be used as the reference indicator for the early diagnose of AP.

关 键 词：急性胰腺炎 肿瘤坏死因子Α 肝细胞生长因子 

分 类 号：R5[医药卫生—内科学]