First Total Synthesis of 6-Oxodendrolasinolide  

作　　者：Yi LI Tao ZHANG Yu Lin LI 

机构地区：[1]State Key Laboratory of Applied Organic Chemistry, Institute of organic chemistry, Lanzhou University, Lanzhou 730000 [2]Minsheng Group Shaoxing Pharmaceutical Co. Ltd., Shaoxing 312071

出　　处：《Chinese Chemical Letters》2006年第2期147-149,共3页中国化学快报（英文版）

基　　金：financially supported by the National Natural Science Foundation of China(Grant No.20072012);the Special Research Grant for Doctoral Sites in Chinese Universities(Grant No.20010730001).

摘　　要：An efficient total synthesis of 6-oxodendrolasinolide 1, a new farnesane-based homosesquiterpene lactone, starting from geraniol 2 through twelve steps is described. Our work involved two key steps： （1） regioselective alkylation of the anion of vinyldithian 5 with allylic chloride 31, （2） Corey＇s oxidative lactionization method2.An efficient total synthesis of 6-oxodendrolasinolide 1, a new farnesane-based homosesquiterpene lactone, starting from geraniol 2 through twelve steps is described. Our work involved two key steps： （1） regioselective alkylation of the anion of vinyldithian 5 with allylic chloride 31, （2） Corey＇s oxidative lactionization method2.

关 键 词：Total synthesis BUTENOLIDE homosesquiterpene. 

分 类 号：O623.624[理学—有机化学]