Stereochemistry Control in Direct 1α-Hydroxylation of 5,6-trans-Vitamin D_(3) by Solid Support  

作　　者：Yong Bin HAN Jin Ping CHEN Bai Ning LIU Guo Qiang YANG Yi LI 

机构地区：[1]Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100101 [2]Key Laboratory of Photochemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080

出　　处：《Chinese Chemical Letters》2006年第2期159-162,共4页中国化学快报（英文版）

基　　金：supported by the Major State Basic Research Development Program(Grant No.F2000078100);the National Natural Science Foundation of China(No.20172059);the Found of Chinese Academy of Sciences.

摘　　要：A solid-phase synthesis of 1α-hydroxylation of 5,6-trans-vitamin D3 8 is described.The solid phase resin acts as a special protecting group, which gives a higher stereoselectivity in oxidation step than classical protecting groups. The stereochemistry control is favored by using high crosslinkage polymer support in a poor solvent. This work may be of benefit to the synthesis of vitamin D system.A solid-phase synthesis of 1α-hydroxylation of 5,6-trans-vitamin D3 8 is described.The solid phase resin acts as a special protecting group, which gives a higher stereoselectivity in oxidation step than classical protecting groups. The stereochemistry control is favored by using high crosslinkage polymer support in a poor solvent. This work may be of benefit to the synthesis of vitamin D system.

关 键 词：Vitamin D3 solid-phase synthesis stereochemistry control. 

分 类 号：TQ466.4[化学工程—制药化工]