六氢哒嗪合成方法的改进  

Improving synthesis of hexahydropyridazine

作　　者：杜晓华[1] 戴建辉[1] 范忠明[1] 徐振元[1] 

机构地区：[1]浙江工业大学催化加氢研究中心

出　　处：《农药》2006年第2期95-96,共2页Agrochemicals

基　　金：浙江省教育厅计划项目(20040566)

摘　　要：六氢哒嗪是一种重要的农药和医药中间体,以二甲酰肼和1,2-二氯丁烷为主要原料,经催化环合和醇解2步反应合成六氢哒嗪,总收率77%,产品纯度97.7%。以二氯丁烷代替二溴丁烷可提高原子经济性,降低成本;以醇解代替水解可提高反应速度、简化分离步骤、降低能耗和减少污染。因此该方法是一种较清洁的生产工艺,适于工业化生产。Hexahydropyridazine, an important pesticidal and pharmaceutical intermediate, was synthesized via catalytic cyclization and alcoholysis using diformylhydrazine and 1,2-dichlorobutane as starting reagents, with a total yield of 77% and purity of 97.7%. By replacing dibromobutane with dichlorobutane, atom economy was increased and the cost decreased. Compared with hydrolysis, the alcoholysis provided a faster reaction rate, a simpler separation step, lower energy consumption, and decreased waste. Thus, this process provided a relatively clean production technology suitable for industrial scale manufacturing.

关 键 词：六氧哒嗪 环合 醇解 合成 

分 类 号：TQ252[化学工程—有机化工]