肝细胞生长因子对抗结核药物性肝损的治疗观察  

The effect analysis of pHGF on the anti-tuberculosis drugs liver lesion

作　　者：刘琨[1] 吴碧彤[1] 蒋蓬[1] 卫安娜[1] 顾玉虹[1] 黄广雄[1] 

机构地区：[1]广州市胸科医院,510095

出　　处：《广州医药》2006年第1期70-72,共3页Guangzhou Medical Journal

摘　　要：目的 了解pHGF治疗抗结核药物性肝损的疗效.方法 肺结核患者在抗结核治疗过程中出现抗结核药物性肝损，且达到停药标准时，实验组每天用120μg的pHGF加入生理盐水250ml中静滴，对照组则以维生素C2g替代pHGF。两组疗程均为25-30天。疗程满后再次复查肝功以评定疗效，统计两组的疗效，结果以X^2检验，P〈0．05为差异有显著性,结果 实验组和对照组治疗有效率分别为93．3％和63．3％（P〈0．05），两者存在显著性差异。结论提示pHGF对治疗抗结核药物性肝损有效。Objective To observe the effect of pHGF on the tuberculosis patients with anti-tuberculosis drugs liver lesionl. Methods The treatment group was given pHGF at a does of 120μg·d^-1 for 25-30 days. dissolved with 0.9% concentration N. S 500 ml by intraventous drip and control group was given vitamini C at a dose of 2. 0 g·d^-1 instead at the same time take the norman liver function as effective in therapy after retest the liver function. Compare the effectvie rate and sinificant differance between the two groups using X^2 , there were significant difference between them if P 〈0.05. Results The effective rate of the treatment group （93.3%） was higher than the control group （63.3%） （P 〈0. 05） , there were significant difference between them. Conclusion pHGF is effective in therapy of amti-tuberculosis drugs liver lesion.

关 键 词：促肝细胞生长因子 结核 药物 肝损 

分 类 号：R521[医药卫生—内科学]