36株脑膜脓毒金黄杆菌体外抗菌活性分析  

Antimicrobial Sensitivity of Chryseobacterium meningosepticum:Analysis of 36 Clinical Isolates

作　　者：董云秋[1] 张晓炜[1] 孔宪玺[1] 

机构地区：[1]首都医科大学附属北京同仁医院,北京100730

出　　处：《中华医院感染学杂志》2006年第1期96-98,共3页Chinese Journal of Nosocomiology

摘　　要：目的 探讨脑膜脓毒金黄杆菌（Chryseobacterium meningosepticum）对于临床诊断及治疗的意义，筛选体外抗菌活性较好的抗菌药物，指导临床合理用药。方法回顾性调查分析2003年的临床资料，对分离出的36株脑膜脓毒金黄杆菌用微量肉汤稀释法检测其最小抑菌浓度（MIC），同时检测脑膜脓毒金黄杆菌产生金属争内酰胺酶的情况。结果36株脑膜脓毒金黄杆菌全部检测出金属β-内酰胺酶；药敏结果显示，体外抗菌活性较好的抗菌药物依次是万古霉素（100．0％）、头孢噻肟／克拉维酸（100．0％）、哌拉西林／舒巴坦（91、7％）、头孢哌酮／舒巴坦（88．9％）、哌拉西林／他唑巴坦（86．1％）、克林霉素（72．2％）、哌拉西林（44．4％），其余21种抗菌药物体外抗菌活性均在8．3％～0之间。结论脑膜脓毒金黄杆菌是多重耐药菌，多发生于年老体弱、住院时间长、基础病较重、免疫力低下的患者；治疗脑膜脓毒金黄杆菌，可选用万古霉素、头孢噻肟／克拉维酸、哌拉西林／舒巴坦、头孢哌酮／舒巴坦、哌拉西林／他唑巴坦、克林霉素。OBJECTIVE To approach to the point of clinical diagnosis and treatment in patients with Chryseobacterium meningosepticum （CM） infection, and test the high sensitivey antibiotic in order to provide evidence for clinical rational drug utilization. METHODS We had retrospectively analyzed the 36 clinical infections with CM during 2003. A microdilution broth method was used to detect the C. meningosepticum MIC and metallo-β-lactamasesproduction. RESULTS C. meningosepticum infections related to the critical underlying diseases, old age, stay in hospital, nosocomial infections and broad spectrum antibiotics use. Metallo-β-lactamases-producing accounted for 100% in all CM isolates. CM were susceptible or partly susceptible to VAN, CTX/CA, PIP/SU, CFP/SU, PIP, CIA, PIP which were 100%,100%, 91. 7%, 88. 9%, 86. 1%, 72. 2%, and 44. 4%, respectively. The susceptibility to other 21 kinds of antimicrobials were in 8.3%. CONCLUSIONS CM is multi-rug resistant. The main risk factors of CM infection are old age, long-term in hospital, critical underlying disease, and decreased immunological function. VAN, CTX/CA, PIP/SU, CFP/SU, PIP, CIA, and PIP are the effective antibiotics against CM.

关 键 词：脑膜脓毒金黄杆菌 药敏试验 危险因素 

分 类 号：R378.99[医药卫生—病原生物学]