高分子量的聚L-谷氨酸的合成与表征  

Synthesis and Characterization of Poly-L-glutamic Acid with a High Molecular Weight

作　　者：曹田[1] 尹静波[1] 罗坤[1] 陈红丹[1] 陈学思[2] 

机构地区：[1]上海大学材料学院高分子系,上海201800 [2]中国科学院长春应用化学研究所高分子物理与化学国家重点实验室,长春130022

出　　处：《高等学校化学学报》2006年第2期369-371,共3页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金(批准号:50473061);上海市教委发展基金(批准号:03AK21);上海市科委基础研究重点项目(批准号:05JC14067)资助

摘　　要：采用三乙胺为催化剂经过氨基酸羧酸酐单体的开环聚合和脱保护基，制备了高分子量聚L-谷氨酸．实验结果表明。合成的高分子量聚L-谷氨酸黏均分子量控制在70000-350000左右．单体和引发剂的摩尔比n（A）／n（I）大于50时。分子量与n（A）／n（I）无关．Poly-L-glutamic acid with a high molecular weight was prepared by chemical synthesis. The structures of PBLG and PLGA were confirmed by FTIR and ^1H NMR spectroscopies and their molecular weights were measured by GPC and viscosity measurements. The results show that the average molecular weight of poly-L-glutamic acid is about 7×10^4-35×10^4. Furthermore, when the anhydride-initiator malar ratio n（A）/n（I） 〉50, the average molecular weight was independent of the amount of triethylamine initiator.

关 键 词：L-谷氨酸 L-谷氨酸苄酯 聚-L-谷氨酸苄酯 聚-L-谷氨酸 

分 类 号：O631[理学—高分子化学]