20种清热解毒中药对耐甲氧西林金黄色葡萄球菌体外抑菌的初步观察  

Inhibition Effects of 20 Heat-clearing and Toxin-resolving Chinese Medical Herbs on MRSA in vitro

作　　者：杨明炜[1] 陆付耳[1] 徐丽君[1] 刘艳娟[1] 陈茹[2] 

机构地区：[1]华中科技大学同济医学院附属同济医院中西医结合研究所,武汉430030 [2]华中科技大学同济医学院附属同济医院检验科

出　　处：《中国药师》2006年第2期141-142,共2页China Pharmacist

基　　金：国家自然科学基金资助课题(NO:39900198)

摘　　要：目的:筛选对耐甲氧西林金黄色葡萄球菌(MRSA)具有抑菌作用的中药。方法:采用液体试管二倍稀释法比较观察 20种常用清热解毒中药对MRSA和甲氧西林敏感金黄色葡萄球菌(MSSA)的体外抑菌作用。结果:16种清热解毒中药对 MRSA、MSSA有不同程度的抑菌作用,其中以黄连抑菌效果最为明显,MIC仅为1．95 mg·ml-1,其它各中药对MRSA和MSSA 的抑菌作用强度基本相同。结论:大部分清热解毒中药对MRSA具有抑菌作用,MRSA对清热解毒中药无抗药性。Objective： To screen the herbs with the inhibition effect on methicillin-resistant staphylococcus aureaus （MRSA）. Method： The antibacterial experiment of 20 heat-clearing and toxin-resolving Chinese medical herbs on the MRSA and methicillin-sensitive staphylococcus aureaus （MSSA） was performed by the liquid tube double dilution method , and the MIC was determined. Result： sixteen herbs had inhibition effects on the MRSA and MSSA in different degree, among which Rhizoma coptidis had the strongest effect and MIC was 1.95 mg· ml^- 1. Furthermore, the degree of inhibition effect of all Chinese medical herbs on both MRSA and MSSA was almost the same. Conclusion： Most of heat-clearing and toxin-resolving Chinese medical herbs had the inhibition effects on the MRSA and MRSA are not resistant to them.

关 键 词：清热解毒中药 耐甲氧西林金黄色葡萄球菌(MRSA) 抑菌作用 

分 类 号：R378.11[医药卫生—病原生物学]