青少年女性中长跑运动员集训前后体能变化与中药的调控作用  

Changes of physical and immune function and the adjustment with traditional Chinese medicine in female adolescent athletes of middle-distance race before and after training

作　　者：郭广宏[1] 田亚平[1] 宋淑珍[1] 汪德清[1] 

机构地区：[1]解放军总医院生化科,北京市100853

出　　处：《中国临床康复》2006年第3期120-123,共4页Chinese Journal of Clinical Rehabilitation

基　　金：国家自然科学基金重点资助项目(20133020)~~

摘　　要：目的:观察青少年女性中长跑运动员这一特殊群体在大运动量集训期前后血清细胞因子及生化指标的变化,探讨运动应激条件下运动员机体变化和细胞因子免疫网络的应答机制以及纯中药制剂--纳米力谷源胶囊对其的调节作用。方法:于2004-06选择北京市某体校青少年女性中长跑运动员20名,为运动员组。又分为运动员对照组和运动员服药组,每组10名。取自无免疫性疾病、无现症、体检健康的青少年女性10名,为正常对照组。运动员服药组服用纳米力谷源胶囊(北京长城制药厂生产,批号:20040201,所含成分为葛根素、精氨酸和玉米抗氧化活性物质),3次/d,2粒/次。两组运动员共同参加训练,使用相同的训练方案:训练时间2004-06-22/07-28,共5周。每日上午:20km×7次/周×5周=700km;下午:节奏跑10km×3次/周×5周=150km,随意跑40min×2次/周×5周=400min,其余两天下午休息。运动员组休整后于2004-06-21取第1次血,第2天开始5周集训,并于集训后2004-07-29取第2次血。应用EVIDENCE180全自动化学发光生物芯片分析仪和HITACHI7600型全自动生化分析仪对20名青少年女性中长跑运动员集训前后及服药后血液标本分别进行12项细胞因子(白细胞介素1α、白细胞介素1β、白细胞介素2、白细胞介素4、白细胞介素6、白细胞介素8、白细胞介素10、血管内皮生长因子、γ-干扰素、表皮生长因子、单核细胞趋化性肽1、肿瘤坏死因子α)和33项生化指标(三酰甘油、胆固醇、载脂蛋白A1、载脂蛋白B、高密度脂蛋白C、低密度脂蛋白C、谷丙转氨酶、谷草转氨酶、总蛋白、血清白蛋白、总胆红素、直接胆红素、总胆汁酸、钠、钾、氯、二氧化碳、钙、磷、镁、铁、不饱和铁结合力、总铁结合力、葡萄糖、尿素氮、肌酐、尿酸、肌酸激酶、乳酸脱氢酶、碱性磷酸酶、γ-谷氨酰转肽酶、淀粉酶、肌酸激酶同工酶)的定量检AIM： To study the physical and immune function of female adolescent middle-distance race athletes in stage of fore-and-aft training and evaluate the adjusted effect of nanometer-particulate ligu yuan capsule, a traditional Chinese herb. METHODS： In June 2004, 20 female adolescent mlddle-distance race athletes were selected from a athletic school of Beijing and divided into two groups： control group and medication group with 10 athletes in each group. Ten healthy female adolescents were selected as normal control group. Athletes in medication group were treated with nanometerparticulate ligu yuan capsule with 3 times per-day and 2 capsules per-time. Athletes in the two groups were trained together with the same training plan： training period was from June 22, 2004 to July 28, 2004, total 5 weeks. They run 20 km every morning totally 700 km during 5 weeks, tempo run 10 km in the afternoon 3 times per-week totally 150 km during 5 weeks, random run 40 rain in the afternoon 2 times per-week totally 400 minutes during 5 weeks, and the other two afternoon they could rest. All of 20 athletes were phlebotonfized the first time at June 21, 2004 after a fond rest period and phlebotomized the second time at July 29, 2004 after 5 weeks＇ training. In order to evaluate the effect which caused by exercise hyperirritability, 12 different serum cytokines （interleakine-1α, interleukine-1β, interleukine-2, interleukine-4, interleukine-6, interleukine-8, interleukine-10, vascular endothelial growth factor, interferon γ, epidermal growth factor, monocyte ehemoattractant protein-1, tumor necrosis factor α） and 33 different biochemical tests （triglyceride, cholesterol, apolipeprotein A1, apolipoprotein B, high density lipoprotein cholesterol, low density lipoprotein cholesterol, alanine aminotransferase, aspartate aminotransferase, total protein, albumin, total hilirubin, direct bilirubin, total bile acid, sodium, potassium, chloride, carbon dioxide, calcium, phosphorus, magnesium, iron, Unsaturated Iron Binding Ca

关 键 词：青少年 女性 体育运动 细胞因子类 中药疗法 调控作用 中药制剂 

分 类 号：R285[医药卫生—中药学] R87[医药卫生—中医学]