Enantioselective Addition of Phenylacetylene to Ketones Catalyzed by Titanium（IV） Complexes of N-Sulfonylated β-Amino Alcohols  

作　　者：王少华 涂永强 陈鹏 

机构地区：[1]tate Key Laboratory of Applied Organic Chemistry & Department of Chemistry, Lanzhou University, Lanzhou, Gansu 730000, China

出　　处：《Chinese Journal of Chemistry》2006年第2期165-168,共4页中国化学（英文版）

基　　金：Project supported by the National Natural Science Foundation of China （Nos. 29925205, 30271488, 20021001 and 203900501）.

摘　　要：The easily prepared and recoverable chiral N-sulfonylated fl-amino alcohol 2 in combination with Ti（OPr-i）4 was found to be an effective chiral catalyst for the enantioselective addition of alkynylzinc to ketones, which gave the useful products, i.e. chiral tertiary propargyl alcohols, with the ee up to 92%.The easily prepared and recoverable chiral N-sulfonylated fl-amino alcohol 2 in combination with Ti（OPr-i）4 was found to be an effective chiral catalyst for the enantioselective addition of alkynylzinc to ketones, which gave the useful products, i.e. chiral tertiary propargyl alcohols, with the ee up to 92%.

关 键 词：asymmetric alkynylation asymmetric catalysis KETONE N-sulfonylated β-amino alcohol tertiary propargylic alcohol 

分 类 号：O625.12[理学—有机化学] O625.42[理学—化学]