顺铂壳聚糖微球制备工艺的研究  

Studies on the preparation procedure of cisplatin chitosan microspheres

作　　者：王亚敏[1] 石庭森[1] 

机构地区：[1]军事医学科学院毒物药物研究所

出　　处：《军事医学科学院院刊》1996年第3期195-198,共4页Bulletin of the Academy of Military Medical Sciences

摘　　要：选择壳聚糖为材料，用乳化化学交联技术制备顺铂壳聚糖微球。研究了影响微球制备的因素，在此基础上选择壳聚糖浓度（因素Ａ）、水／油相体积比（因素Ｂ）、搅拌速度（因素Ｃ）、药物与载体材料用量比（因素Ｄ）、油相类型（因素Ｅ）、壳聚糖种类（因素Ｆ）及固化时间（因素Ｇ）七个因素，每个因素选择三水平，用正交实验设计安排实验，并以微球载药量、药物包封率、粒子分布百分数为指标优化微球的制备工艺。Cisplatin chitosan microspheres (CDDP DAC MS) were prepared by emulsion chemical crosslink technique. Various factors affecting the preparation of CDDP DAC MS were studied. 7 factors and 3 levels of each factor were chosen and the orthogonal experimental design was applied to optimize the preparation procedure of CDDP DAC MS with respect to embedding rate, drug content (w/w, %), and percentage of particles in 50-120 μm of CDDP DAC MS. The reproducibility of optimized preparation procedure was good.

关 键 词：甲壳质 药物载体 顺铂 壳聚糖 微球 

分 类 号：R318.08[医药卫生—生物医学工程] R944[医药卫生—基础医学]