连续性血液净化治疗对脓毒症患者凝血功能的影响  

Effect of continuous blood purification on the function of coagulation in the patients with severe sepsis

作　　者：陶晓根[1] 王锦权[1] 承韶辉[1] 赵劲松[1] 

机构地区：[1]安徽医科大学附属省立医院ICU,安徽合肥230001

出　　处：《中国急救医学》2006年第2期90-92,共3页Chinese Journal of Critical Care Medicine

基　　金：安徽省卫生厅科研基金课题(No.2002B007)

摘　　要：目的观察连续性血液净化(CBP)治疗对脓毒症患者凝血功能的影响。方法对19例脓毒症患者行30例次CBP治疗,在治疗前、停止治疗时及治疗后第2天观察患者APACHEⅡ评分及凝血功能的相关参数的变化。结果治疗后APTT、TT较治疗前延长,差异有显著意义;治疗后第2天,APTT、TT仍延长,但无统计学意义,PT、Fg无明显变化,APACHEⅡ评分、D-D较治疗前下降,差异有显著意义。结论CBP是治疗严重脓毒症的有效措施之一,能改善其凝血功能,而改善凝血功能的机制可能与多种因素有关。Objective To evaluate the effect of continuous blood purification （CBP） on the function of coagulation in the patients with severe sepsis , Methods APACHE Ⅱ score and some parameters of coagulation function in pre - CBP, post - CBP and the 2nd day after CBP were studied and compared in 19 patients with severe sepsis. Results APTT,TT were longer in post - CBP than in pre- CBP（ P 〈 0.05）, and still long on the next day of CBP but there was no statistical significance（ P 〉 0.05）. There were no significant difference in PTF, Fg in the pre - CBP, post - CBP and the next day of CBP. APACHE Ⅱ score, D - D level in the post - CBP and the next day of CBP lowered obviously, compared with pre - CBP （ P 〈 0.01 ）. Conclusion CBP is one of effective methods for the patients with severe sepsis, and can improve the coagulation function of these patients.

关 键 词：连续性血液净化 脓毒症 凝血 

分 类 号：R459.5[医药卫生—治疗学]