蒙族高血压患者ACE基因多态性与胰岛素抵抗  

Association between angiotension-converting enzyme gene polymorphism and insulin resistance in Mongolian hypertensives

作　　者：叶宏[1] 刘丽娟[1] 佟伟军[2] 刘国玉[3] 李永山 黄桂蓉[1] 王健[3] 张永红[2] 

机构地区：[1]哈尔滨医科大学公共卫生学院流行病学教研室,哈尔滨150081 [2]苏州大学放射医学与公共卫生学院流行病学教研室 [3]内蒙古通辽市疾病预防控制中心 [4]内蒙古科左后旗卫生防疫站

出　　处：《中国公共卫生》2006年第2期147-148,共2页Chinese Journal of Public Health

基　　金：国家自然科学基金(30040040)

摘　　要：目的探讨蒙古族高血压人群血管紧张素转换酶(ACE)基因I/D多态性与胰岛素抵抗及血脂的关系。方法选择115例高血压者和114例血压正常者检测血脂、血糖和胰岛素水平;分析高血压组ACE基因I/D多态性与胰岛素抵抗及血脂的关系。结果在高血压组及正常对照组中,未发现ACE基因I/D多态性胰岛素抵抗及血脂有关联(P>0.05)。结论蒙古族高血压人群中ACE基因I/D多态性与胰岛素抵抗及血脂水平无关联。Objective To explore the association between angiotensin-converting enzyme（ACE）gene I/D polymorphism and insulin resistance and blood lipid in Mongolian hypertensives. Methods 115 Mongolian hypertensives and 114 Mongolian normotensives were selected to test blood lipid, blood glucose and insulin; analyzing examining the insertion/deletion polymorphism of ACE gene in hypertensives and normotensives. Results These was no significant difference to be found between ACE gene I/D polymorphism and insulin resistance and blood lipid in Mongolian hypertensives and normotensives （ P 〉 0.05）. Conclusion The ACE gene polymorphism was not related to insulin resistance and blood lipid in Mongolian hypertensives.

关 键 词：高血压 血管紧张素转换酶 ACE 基因 胰岛素抵抗 血脂 蒙古族 基因多态性 

分 类 号：R544.1[医药卫生—心血管疾病]