碳糊电极阳极吸附伏安法测定阿司咪唑  

Anodic adsorptive voltammetric determination of astemizole at a carbon paste electrode

作　　者：易兰花[1] 费俊杰[1] 黎拒难[1] 夏殊[1] 

机构地区：[1]湘潭大学化学学院,湖南湘潭411105

出　　处：《化学试剂》2006年第1期30-32,共3页Chemical Reagents

基　　金：中科院长春应化所电分析化学国家重点实验室基金(SKLEAC2003-5);湖南省教育厅科学基金(01C113)资助项目

摘　　要：在0．40mol／L的HAc-NaAc（pH4．6）缓冲液中，阿司咪唑在碳糊电极（CPE）上有一灵敏的吸附氧化伏安峰，峰电位为0．84V（vs．SCE）。该氧化峰的二阶导数峰电流与阿司咪唑的浓度在2．0×10^-9-1．0×10^-7mol／L（富集90s）范围内呈良好的线性关系，相关系数，为0．9980，检出限为1．0×10^-9mol／L，探讨了阿司咪唑在碳糊电极上的伏安性质和电极反应机理，并且成功地应用于息斯敏片含量的测定，加标回收率在99．7％-100．3％之间，结果与紫外分光光度法基本吻合。A sensitive anodic adsorptive voltammetric method has been developed for the determination of ultra trace amount of astemizole at a carbon paste electrode（CPE） in the current paper. The astemizole could be adsorbed on the surface of the CPE in 0.40mol/L HAc-NaAc buffer solution （pH 4.6）and a second derivative oxidation peak was obtained at around 0.84V （vs. SCE）.The result showed that the oxidation current was linear with astemizole concentration in the range of 2.0×10^-9-1.0×10^-7moL/L under optimal experiment conditions. For a 120s accumulation, a low detection limit of 1.0×10^-9moVL was obtained（ S/N=3）. The voltammetric behaviour of astemizole at the carbon paste electrode was investigated and possible electrode reaction mechanism was proposed, The proposed method was applied to determine trace astemizole in the astemizole tablet directly and the results were in good agreement with the reference values obtained with the spectrophotometric method.

关 键 词：阿司咪唑 阳极吸附伏安法 碳糊电极 

分 类 号：O657.1[理学—分析化学]