阿托伐他汀对冠心病患者血浆一氧化氮、纤维蛋白原、D-二聚体水平的影响  

Effect of atorvastatin on the levels of plasma nitrogen monoxidum fibrinogen and D-dimer in coronary heart disease

作　　者：孙一荣[1] 张云[1] 孙玉新[1] 郭景瑞[1] 

机构地区：[1]聊城市第二人民医院心内科,山东省252600

出　　处：《实用诊断与治疗杂志》2006年第2期84-85,共2页Journal of Practical Diagnosis and Therapy

基　　金：聊城市市级科研立项课题

摘　　要：目的:研究阿托伐他汀对冠心病患者血浆一氧化氮、纤维蛋白原、D-二聚体水平的影响。方法:随机选择冠心病患者120例,入选患者随机单盲分为阿托伐他汀组60例,常规治疗组60例,另外随机选择40例正常人做对照组。采用比色法测定一氧化氮含量;血凝仪法测定纤维蛋白原含量;胶体金法测定D-二聚体含量。结果:冠心病患者血浆一氧化氮水平明显下降,与对照组比较有显著性差异(P<0.01),血浆纤维蛋白原、D-二聚体水平明显升高,与对照组比较有显著性差异(P<0.01);阿托伐他汀组和常规治疗组治疗前三者水平比较无显著性差异(P>0.05);阿托伐他汀组治疗后一氧化氮水平明显升高,纤维蛋白原、D-二聚体水平明显降低,与常规治疗组治疗后比较有显著性差异(P均<0.01);结论:阿托伐他汀可通过保护血管内皮功能及改善血液流变学状态,从而改善心肌供血,抑制冠心病的发生发展过程。Objective To study the effects of atorvastatin on the levels of plasma nitrogen monoxidum, fibrinogen and D-dimer. Methods One hundred and twenty patients with coronary heart disease were randomly divided into 2 groups, the atorvastation therapeutic group （n=60） and conventional therapeutic group （n=60）. The other 40 healthy persons were recruited as control group. The levels of plasma nitrogen monoxidum were determined with colorimetry. The levels of plasma fibrinogen were determined with automated coagulometer method. The level of D-dimer was dertermined with colloidal gold method. Results The level of plasma nitrogen monoxidum was decreased significantly and the levels of fibrinogen, D-dimer were increased significantly in the patients of coronary heart disease compared to those in control group（P〈0. 01 ,P〈0. 01 ,P〈0. 01）. There was no significant difference in the levels of plasma nitrogen monoxidum, fibrinogen and Ddimer between the atorvastation therapeutic group and conventional therapeatic group （P〉0. 05） before the treatment. After 8-week atorvastatin therapy, the level of plasma nitrogen monoxidum was increased significantly,the levels of plasma fibrinogen and D-dimer were decreased significantly（P〈 0. 01）. There was no significant difference in the conventional therapeutic group （P〉0. 05）. Conclusion It is suggested that the therapy with atorvastatin could protect vascular endothelial function, improve the blood supply of cardiac muscle, and inbibit the process of coronary heart disease.

关 键 词：冠心痛 阿托伐他汀 一氧化氮 纤维蛋白原 D-二聚体 

分 类 号：R541.4[医药卫生—心血管疾病]