干扰素鞘内注射治疗病毒性脑炎的疗效及鞘内注射前后脑脊液中干扰素浓度的测定  

The effect of interferon intrathecal injection curing virosis encephalitis and measurement of the interferon concentration in the cerebrospinal fluid before and after the treatment

作　　者：高宗勋[1] 宋义琴[1] 唐卉[1] 魏艳红[1] 王杰英[1] 王刃[1] 雷淑琴[1] 张立红[1] 

机构地区：[1]河北省保定市儿童医院,保定071051

出　　处：《中华妇幼临床医学杂志（电子版）》2006年第1期18-20,共3页Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition)

基　　金：保定市科技局科研基金资助项目(01F005)

摘　　要：目的探讨鞘内注射干扰素治疗病毒性脑炎的疗效,并观察脑脊液中干扰素浓度在鞘内注射前、后的变化。方法将76例病毒性脑炎患儿随机分为治疗组(38例)和对照组(38例)。治疗组除在常规治疗基础上鞘内注射干扰素外,还按干扰素注射的剂量分为大剂量组与小剂量组。治疗前、后分别采集脑脊液,用微量细胞病变抑制法测定脑脊液中干扰素浓度。结果治疗组与对照组比较,在临床症状改善方面治疗组明显优于对照组,差异有显著性。治疗组两种不同剂量干扰素疗效比较,大剂量组临床症状的改善优于小剂量组。结论鞘内注射干扰素是一种治疗病毒性脑炎的有效方法,且脑脊液中干扰素浓度的高低与临床疗效呈平行关系。Objective To investigate the effect of interferon intrathccal injection curing virosis encephalitis and observe the concentration change of interferon in cerebrospinal fluid before and after the treatment. Methods Devided randonly 76 virosis encephalitis sufferers to treatment group （38 eases） and control group（38 cases）. Treatment group treated with interferon intrathecal injection except for routine treatment. Then we devided the treatment group to big dose interferon group and little dose group ,We gathered the cerebrospinal fluid before and after treatment,Then measured the concentration of interferon with microcytopathie inhibition assay. Results There was a statistical difference between treatment group and control group in improving the clinical signs. The big dose group was better than the little dose group too. Conclusion Interferon intratheeal injection in a good method to treat vivosis encephalitis, and there was a linear relationship between the interferon coucentration in the cerebrospinal fluid and the clinical effect.

关 键 词：病毒性脑炎 鞘内注射 干扰素 浓度 

分 类 号：R725.1[医药卫生—儿科]