淫羊藿甙扩血管作用机制的研究  

Vasodilating mechanism of epimedium icariine

作　　者：关利新[1] 衣欣[1] 杨履艳[1] 吕怡芳[1] 

机构地区：[1]牡丹江医学院药理教研室,白求恩医科大学药理教研室

出　　处：《中国药理学通报》1996年第4期320-322,共3页Chinese Pharmacological Bulletin

摘　　要：本实验以离体兔胸主动脉条为标本，对淫羊藿甙（ＥＩ）扩血管作用的机制进行了探讨。ＥＩ２０，４０ｍｇ·Ｌ－１对ＮＥ、ＫＣｌ及ＣａＣｌ２收缩兔主动脉条的量效曲线呈非竞争性拮抗作用；ＥＩ３０ｇ·Ｌ－１能明显抑制ＮＥ诱导的兔主动脉条依赖于细胞外钙的收缩反应，对依赖于细胞内钙的收缩反应没有影响；ＥＩ３０ｇ·Ｌ－１松驰主动脉条的作用与阻断α受体或激动β受体无关。提示ＥＩ的扩血管作用机制可能与其对钙通道的阻滞作用有关。The epimedium icariine(EI) was isolated from the stem and leaves of epimedium brevicornum Maxim,and the vasodilating mechanism of EI was studied on the isolated aortic strips of rabbits.EI(20,40 mg·L-1) could non-competitively antagonize the dose-response curves of norepinephrine(NE),potassium chloride and calcium chloride.At the concentration of 30 mg·L-1,EI significantly inhibited the extracellular Ca2+-dependent contraction of aortic strips induced by NE,however,it didn't inhibit the intracellular Ca2+-dependent contraction of aortic strips induced by NE.EI(30 mg·L-1) pro duced neither α-adrenoceptic stimulating nor β-a drenoceptic blocking effects.These results indicated that the vasodilating mechanism of EI might have associated with its blocking calcium channels.

关 键 词：淫羊藿甙 胸主动脉 淫羊藿 扩张血管作用 

分 类 号：R285.5[医药卫生—中药学] R282.710.5[医药卫生—中医学]