中国汉族、维吾尔族、哈萨克族人群中可溶性细胞黏附分子的表达与CYP2D6基因多态性  

The expression of sICAM-1 and the gene polymorphism of CYP2D6 in Han,Urghur and Hasake nationality in China

作　　者：李国昌[1] 杨军[1] 周婷[1] 陈志刚[1] 

机构地区：[1]石河子大学医学院第一附属医院,新疆石河子832008

出　　处：《中国医院药学杂志》2006年第2期123-125,共3页Chinese Journal of Hospital Pharmacy

基　　金：国家自然科学基金项目(编号:39960080)

摘　　要：目的：探讨可溶性细胞黏附分子-1在汉族、综合症吾尔族、哈萨克族正常人血清中的表达水平是否存在民族间差异以及与CYP2D6基因多态性是否有关。方法：ELISA双抗体夹心法。结果：血清中可溶性细胞黏附分子-1含量：汉族为35～1086μg·L^-1，维吾尔族为40～1024μg·L^-1，哈萨克族为45～975μg·L^-1。结论：可溶性细胞黏附分子-1的含量在汉族与维吾尔族、汉族与哈萨克族、维吾尔族与哈萨克族之间差异均无显著性．OBJECTIVE To study the different expression of sICAM-1 in healthy human serum in HaM, Urghur and Hasake nationalities, and to investigate the relation between the express and the gene polymorphism of CYP2D6. METHODS ELISA with Double Antibody Sandwich was applied. RESULTS The contents of sICAM-1 in serum ranged from 35 - 1 086μg·L^-1in HaM, 40 - 1 024 μg·L^-1 in Urghur and 45 -975μg·L^-1 in Hasake respectively. CUNCLUSION The content of sICAM-1 has no significant difference between HaM and Urghur,Han and Hasake,Hasake and Hasake .

关 键 词：汉族 维吾尔族 哈萨克族 可溶性细胞黏附分子-1 CYP2D6 多态性 

分 类 号：R969[医药卫生—药理学]