太子参水提物的抗氧化活性  

Study on antioxidative activity of the extract from Pseudostellaria heterophylla

作　　者：张振明[1] 许爱霞[1] 葛斌[1] 袁逸铭[2] 

机构地区：[1]甘肃省人民医院,甘肃兰州730000 [2]兰州医学院第二临床医学院,甘肃兰州730000

出　　处：《中国医院药学杂志》2006年第2期147-149,共3页Chinese Journal of Hospital Pharmacy

基　　金：甘肃省科学事业费科研项目(QS041-C33-20)

摘　　要：目的:研究太子参水提物的抗氧化活性及其机制。方法:用D-半乳糖造衰老小鼠模型,受试药组衰老小鼠分别灌胃生药量1.44,2.88,5.76g.kg-1.d-1的太子参水提物,qd,共7周,观察其对衰老模型小鼠抗氧化系统的影响。结果:太子参水提物能使心、肝、肾组织中丙二醛(MDA)不同程度下降;超氧化物歧化酶(SOD)及谷胱甘肽过氧化物酶(GSH-Px)活力不同程度提高;脑组织中脂褐质(LF)不同程度下降。结论:太子参水提物通过清除.OH,提高SOD及GSH-Px活力而发挥抗氧化活性。OBJECTIVE To study the antioxidative activity and its mechanism of the water extract from Pseudostellaria heterophylla （EPH）. METHODS The effect of EPH was observed on antioxidative system of senile model mice caused by D-galatose （ Dgal） which were administered with the extract equivalent to 1.44 g, 2.88 , 5.76 g·kg^-1·d^-1 plant drug once a day for 7 weeks respectively. RESULTS Malondiahtehyde （MDA） differently dropped, the activities of superoxide dismutase （SOD） and glutathione peroxidase（GSH-Px） differently ascended in heart,liver and kidney, lipofuscin （LF） differently descended in brain of senile model mice which were administered with EPH. CONCLUSION EPH exerts its a,uioxidative activity by eliminating·OH free radicals,increasing activities of SOD and GSH-Px.

关 键 词：太子参水提物 氧自由基 活性氧 脂质过氧化 

分 类 号：R285.5[医药卫生—中药学]