外用咪喹莫特对尖锐湿疣激光术后复发的预防作用  

Effect of imiquimod cream on preventing recurrence of condyloma acuminatum following laser treatment

作　　者：马殷浩 张庆江[2] 朱宇翔[2] 

机构地区：[1]浙江省海宁市人民医院药剂科,海宁314400 [2]浙江省嘉兴市第一医院皮肤性病科,嘉兴314000

出　　处：《中国临床药学杂志》2006年第1期27-28,共2页Chinese Journal of Clinical Pharmacy

摘　　要：目的观察咪喹莫特乳膏局部外用预防尖锐湿疣激光术后复发的效果。方法将107例尖锐湿疣患者随机分成2组,治疗组在CO2激光术后局部外用咪喹莫特乳膏8 wk,对照组单纯用CO2激光治疗,随访6 mo,观察2组患者有无疣体复发。结果随访6 mo,治疗组的复发率为12.50%,对照组的复发率为45.10%(P<0.01)。结论咪喹莫特乳膏局部外用对尖锐湿疣激光术后复发具有预防作用。AIM To observe the effect of imiquimod 5 % cream for topical application on preventing recurrence of condyloma acuminatum after CO2 laser treatment. METHODS One hundred and seven patients of condyloma acuminatum were randomized into 2 groups： treatment group and control group. The treatment group （ n = 56） was treated with imiquimod 5 % cream topically for 8 wk after CO2 laser therapy. Control group （ n = 51 ） was treated with CO2 laser therapy only, All cases were followed-up for 6 mo to observe the recurrence of wart. RESULTS After 6 mo, the recurrence rate was 12.50% in the treatment group and 45.10% in the control group （P 〈 0.01）. CONCLUSION Using imiquimod 5 % cream topically is effective in prevention of condyloma acuminatum relapse after CO2 laser treatment.

关 键 词：咪喹莫特 尖锐湿疣 CO2激光 复发 

分 类 号：R752.53[医药卫生—皮肤病学与性病学]