奥美拉唑预防危重病患儿应激性上消化道出血疗效观察  

Effect of omeprazole on the prevention of stress upper gastrointestinal bleeding in critical diseased children

作　　者：杨红[1] 何长生[1] 李沫民[1] 高华[1] 

机构地区：[1]河南省南阳市中心医院,河南南阳473000

出　　处：《儿科药学杂志》2006年第1期29-30,共2页Journal of Pediatric Pharmacy

摘　　要：目的:探讨奥美拉唑对危重病患儿应激性上消化道出血的预防效果并进一步研究其机制。方法:122例危重病患儿随机分为两组,对照组给予对症及支持治疗,预防组在对照组治疗基础上加用奥美拉唑0.4mg/次,1次/d,连用7d,对两组患儿上消化道出血的发生率进行比较。结果:预防组上消化道出血的发生率为8.07%,明显低于对照组33.3%,差异有统计学意义(P<0.01)。结论:奥美拉唑能有效地预防危重病患儿应激性上消化道出血的发生。Objective： To study the effect of omeprazole in preventing stress bleeding in critical diseased children. Methods： One hundred and twenty two cases of pediatric critical illness were enrolled in the study, and randomly divided into two groups, the prevention group with omeprazole and the control group with conventional therapy. The omeprazole, 0.4 mg daily, was used in the prevention group for 7 days. The rates of stress with bleeding among the two groups were investigated. Results： The rates of stress with bleeding among the two groups were 8.07% in omeprazole group and 33.3% in control group. The rate of bleeding in omeprazole group was significant lower than that in the control group（P 〈 0.01 ）. Conclusions： Omeprazole can prevent stress upper bleeding in critical diseased children.

关 键 词：奥美拉唑 预防 应激性上消化道出血 

分 类 号：R725.6[医药卫生—儿科]