两亲性二嵌段共聚物MPEG_(44)-b-Phe的合成及其在水溶液中的自组装  

SYNTHESIS OF AMPHIPHILIC DIBLOCK COPOLYMERS MPEG-b-Phe AND THEIR SELF-ASSEMBLY IN WATER

作　　者：李丽颖[1] 孙平川[1] 要旸[1] 周慧静[1] 陈铁红[1] 李宝会[2] 金庆华[2] 丁大同[2] 

机构地区：[1]吸附与分离功能高分子材料国家重点实验室南开大学化学学院 [2]南开大学物理系,天津300071

出　　处：《高分子学报》2006年第1期124-128,共5页Acta Polymerica Sinica

基　　金：国家自然科学基金(基金号20274020;20373029;20374031)资助项目

摘　　要：利用光气法,以三光气和苯丙氨酸为原料,合成了苯丙氨酸酸酐(b-Phe-NCA).用端氨基聚乙二醇单甲醚(MPEG-NH2)作大分子引发剂,引发b-Phe-NCA开环聚合,合成了不同分子量的聚乙二醇单甲醚-聚(L-苯丙氨酸)(MPEG44-b-Phe)AB型二嵌段共聚多肽.利用IR1、H-NMR、GPC对共聚物结构进行了表征.利用TEM研究了二嵌段共聚多肽MPEG44-b-Phe50及MPEG44-b-Phe7在水溶液中的自组装形态,结果表明合成出的两亲性二嵌段共聚物在水溶液中自组装形成胶束,随着嵌段共聚物中亲水嵌段含量的增高,共聚物溶水性增强,其在水溶液中的自组装形态更加均一.Poly（ethyl glycol）-b-poly（L-phenylalanine） AB diblock copolypeptides （MPEG44-b-Phe50 and MPEG44- b-Phe7） were synthesized from Phe-NCA monomer by using ct-methoxy-ω-2-aminoethyl-poly （ethylene glycol） （MPEG-NH2） as the initiator. L-phenylalanine N-carboxyanhydride（b-Phe-NCA） was prepared with the phosgene method（ Fuchs-Farthing method）, through the reaction of amino acids and triphosgene. The macromoleculeas initiator, amino-terminated （MPEG-NH2） was prepared by converting the end group of hydroxyl to amino group. The structure of these copolymers were characterized by means of FTIR. ^1 H-NMR and GPC. The results of these experiments provided direct evidence of the formation of the block copolymers. Self-assembled structures of the synthesized diblock copolymers in water were prepared by the dialysis method and the morphologies of the aggregates were investigated by TEM. The results proved that these amphiphilic diblock copolymers can self-assemble into micelles in water.

关 键 词：聚乙二醇单甲醚 苯丙氨酸 嵌段共聚物 自组装 

分 类 号：O631.3[理学—高分子化学]