Anti-nociceptive role of neuropeptide Y in the nucleus accumbens in rats with inflammation, an effect modulated by mu- and kappa-opioid receptors  

作　　者：LI Jinju YU Longchuan 

机构地区：[1]Laboratory of Neurobiology, College of Life Sciences, and National Laboratory of Biomembrane and Membrane Biotechnology, Peking University, Beijing 100871, China

出　　处：《Progress in Natural Science:Materials International》2006年第2期133-141,共9页自然科学进展·国际材料（英文版）

基　　金：National Natural Science Foundation of China (Grant No. 30370455)

摘　　要：Recent study in our laboratory showed that neuropeptide Y （NPY） plays an antinociceptive role in the nucleus accum hens （NAc） in intact rats. The present study was performed to further investigate the effect of NPY in nocieeptive modulation in the NAc of rats with inflammation, and the possible interaction between NPY and the opioid systems. Experimental inflammation was induced by subcutaneous injection of carrageenan into the left hindpaw of rats. Intra-NAc administration of NPY induced a dose dependent increase of hindpaw withdrawal latencies （HWLs） to thermal and mechanical stimulations in rats with inflammation. The anti-nociceptive effect of NPY was significantly blocked by subsequent intra-NAc injection of the Y1 receptor antagonist NPY28-36, suggesting an involvement of Y1 receptor in the NPY induced anti-nociception. Furthermore, intra-NAc administration of the opioid antagonist naloxone significantly antagonized the increased HWLs induced by preceding intra-NAc injection of NPY, suggesting an involvement of the endogenous opioid system in the NPY-induced anti-nociception in the NAc during inflammation. Moreover, the NPY induced anti-nociception was attenuated by following intra-NAc injection of the μ-opioid antagonist β-funaltrexamine （β-FNA）, and κ-opioid antagonist nor-binaltorphimine （nor-BN1）, but not by δ-opioid antagonist naltrindole, indicating that μ- and κ-opioid receptors, not δ-opioid receptor, are involved in the NPY induced anti-nociception in the NAc in rats with inflammation.在我们的实验室的最近的学习证明 neuropeptide Y (YPY ) 在未经触动的老鼠玩 antinociceptive 角色原子核 accumbens (NAc ) 。现在的学习被执行进一步与发炎，和在 NPY 和 opioid 系统之间的可能的 interation 在老鼠的 NAc 在 nociceptive 调整调查 NPY 的效果。试验性的发炎被角叉菜的 subcutanceous 注射导致一 into 老鼠的左后部的爪。Intra-NAc 管理 fo NPY 与发炎在老鼠导致了后部的爪退却潜伏(HWL ) 的剂量依赖者增加到热、机械的刺激。在导致 NPY 的 anti-nociception 的 Y1 受体的 anti-nociceptive 效果。而且， N1 受体对手 NPY28-36 的 intra-NAc 注射，建议参与反对了增加的 HWL 由 NPY 的前面的 intra-NAc 注射导致了的 signigicantly 反对的 opioid 对手 nalozone 的前面的 intra-NAc 管理导致的增加的 HWL ，在 NPY 建议内长的 opioid 系统的参与-在发炎期间在 NAc 导致了 anti-nociception 。而且， 导致NPY 的 anti-nociception 被 μ-opioid 对手 β-funaltrexamine ( β-FNA )和 κ-opioid 对手 nor-binaltorphimine ( nor-NPI )的后面的 intra-NAc 注射然而并非由 δ-opioid 对手 naltrindole 稀释，显示那 μ-opioid 和 κ-opioid 受体，不是 δ-opioid 受体，与发炎在老鼠在 NAc 在 导致NPY 的 anti-nociception 包含。

关 键 词：nucleus accumbens  neuropeptide Y  Y1 receptor  carrageenan anti-nociception  μ- and κ-opioid receptors 

分 类 号：Q42[生物学—神经生物学]