皮质酮对吗啡急性精神运动兴奋性及行为敏感化的影响  

Effect of Corticosterone on Morphine-induced Psychomotor Effect and Its Sensitization

作　　者：王冬梅[1] 李勇辉[1] 郑希耕[1] 杨晓燕[1] 隋南[1] 

机构地区：[1]中科院心理健康研究室

出　　处：《中国心理卫生杂志》2006年第1期32-34,共3页Chinese Mental Health Journal

基　　金：国家重点基础研究发展计划(973计划;2003CB515404);国家自然科学基金重点项目(30230130;30170324);中科院知识创新工程项目(KSCX2-SW-204-02)

摘　　要：目的:考察皮质酮对吗啡急性精神运动兴奋性和行为敏感化的作用。方法:32只SD大鼠分为四组,腹腔分别给予生理盐水(1ml/kg)、吗啡(2mg/kg)、皮质酮(5mg/kg)、皮质酮/吗啡后,计算机自动记录60分钟大鼠的水平活动量,作为急性精神运动的测量指标。每两天重复测量一次,实验进行14天,七次的水平运动作为行为敏感化的指标。结果:皮质酮/吗啡组表现出明显的精神运动兴奋性(盐水组7175±676,皮质酮/吗啡组10365±503,P<0·05)。对行为敏感化效应而言,吗啡组和皮质酮/吗啡组都形成了明显的行为敏感化(F(6,156)=2·41,P<0·05;F(6,156)=4·27,P<0·01),但组别和时间的交互作用不显著(F(6,78)=1·018,P=0·420),表明皮质酮对吗啡的行为敏感化没有影响。结论:皮质酮增强吗啡的精神运动兴奋性但不影响行为敏感化现象。Objective： To explore the role of corticosterone in morphine - induced acute psychomotor activity and behavioral sensitization. Methods： 32 male SD rats were divided into four groups. Rats were intraperitoneally given saline, morphine, corticosterone and corticosterone/morphine separately. The horizontal locomotor activity was recorded for 60min by the computer trace system automatically. The locomotor activity was measured in every two days for total seven times. Results： The corticosterone/morphine group showed significant morphine- induced acute psychomotor effect comparing with the saline group （saline group 7175 ± 676, corticosterone/morphine group 10365 ± 503, P〈0. 05） . In behavior scnsitizationj the morphine group and the corticosterone/morphine group showed significant behavioral sensitization （ P 〈 0. 05 ）, but the interaction of Group x Time is not significant （ F （ 6, 78 ） = 1.018, P = 0. 420 ）, so the corticosterone had no effect on morphine - induced behavioral sensitization. Conclusion： Corticosterone increased the morphine - induced acute psychomotor activity but did not modify the behavioral sensitization induced by repeated morphine injection.

关 键 词：药物成瘾 动物研究 吗啡 精神运动性 敏感化 

分 类 号：B845.4[哲学宗教—心理学]