屏风固金颗粒制备工艺的研究  

Study on Preparation Technology for Pingfenggujin Granule

作　　者：王爱武[1] 耿晖[1] 吴丽敏[1] 宿莹莹[1] 曲宝妮[2] 

机构地区：[1]山东省立医院天然药物研究中心,山东济南250021 [2]山东中医药大学药学院,山东济南250014

出　　处：《中国中医药信息杂志》2006年第2期45-47,共3页Chinese Journal of Information on Traditional Chinese Medicine

摘　　要：目的优选屏风固金颗粒的最佳制备工艺。方法以黄芪甲苷含量、多糖含量及干膏得率为指标,采用L9(34)正交设计法筛选最佳提取条件。采用UV及ELSD-HPLC法分别对多糖及黄芪甲苷进行含量测定。结果确定的最佳提取工艺为:浸泡时间2.0h、煎煮3次、每次2.0h、加水量为药材总重的10倍。结论优选的提取工艺可行,所采用的含量测定方法准确可靠。Objective To optimize a preparation technique of Pingfenggujin Granule. Methods The technique was determined by the orthogonal design with content of Astragalosides, polysaccharides and the rate of dried extracts. The contents of polysaccharides and Astragalosides were determined by UV and ELSD-HPLC respectively. Results The optimum water-extraction technique was to steep 2.5 h, ten times of water as much as weigh of total drugs and extract three times, 2 h each. Conclusion The optimum technique is feasible, and the method of content determination is accurate and reliable.

关 键 词：屏风固金颗粒 正交试验 制备工艺 ELSD-HPLC 黄芪甲苷 

分 类 号：R283.5[医药卫生—中药学]