葛根芩连微丸中指标成分的体外同步释放研究  

Simultaneous release of index components in Gegen Qinlian Pellets

作　　者：李青坡[1] 游剑[1] 王永圣[1] 赵颖[1] 杨蕾[1] 崔福德[1] 

机构地区：[1]沈阳药科大学药剂教研室,辽宁沈阳110016

出　　处：《中草药》2006年第1期40-44,共5页Chinese Traditional and Herbal Drugs

摘　　要：目的使葛根芩连速释微丸中理化性质差异较大的各指标性成分葛根素、黄芩苷、小檗碱和甘草酸能达到同步释放。方法考察适宜的提高难溶性成分溶出速率的方法,在此基础上制备葛根芩连速释微丸,采用相似因子(f2)法统计分析释放曲线。结果黄芩苷、小檗碱、甘草酸与葛根素释放度的f2值分别为52.27、56.13和75.1。结论4种指标性成分葛根素、黄芩苷、小檗碱和甘草酸基本达到同步释放。Objective To obtain the same release rate of four index components with significant difference of physicochemical characters, puerarin, baicalin berberine and glycyrrhizin in Gegen Qinlian Pellets. Methods Studies on improving the release rate of less soluble components in Gegen Qinlian Pellets were carried out and the parameters were optimized. The release profiles were analyzed by simulating factor （f2）. Results The f2 values for baicalin, berberine and glycyrrhizin vs puerarin were 52.27, 56.13, and 75.1, respectively. Conclusion The result shows that the same release rate of four index components in Gegen Qinlian Pellets is obtained.

关 键 词：葛根芩连微丸 挤出滚圆法 体外释放 

分 类 号：R283.6[医药卫生—中药学] R286.02[医药卫生—中医学]