草珊瑚浸膏的絮凝和膜分离纯化研究  

Application of flocculation and membrane separation in purification of Caoshanhu extract

作　　者：朱才庆[1] 余华[1] 张锐[1] 范其坤[1] 熊胜泉[1] 魏东芝[2] 

机构地区：[1]江西省药物研究所,江西南昌330029 [2]华东理工大学生物反应器工程国家重点实验室,上海200237

出　　处：《中草药》2006年第1期45-48,共4页Chinese Traditional and Herbal Drugs

基　　金：国家"十五"攻关项目(2001BA701A05);江西省重大科技攻关项目(赣科发计字[2002]64号)

摘　　要：目的探讨草珊瑚浸膏的不同预处理方法及对膜分离效果的影响。方法采用各种预处理方法初步比较、通过ZTC1+1Ⅲ型、壳聚糖、明矾絮凝的正交试验设计进一步试验,以与异秦皮啶相关的各种指标考察各种预处理方法的效果及对膜分离效果的影响。结果与ZTC1+1Ⅲ型、壳聚糖、明矾的最佳絮凝工艺相比,微滤预处理后超滤膜分离草珊瑚浸膏的膜通量及异秦皮啶膜透过率最大、运行时间最短、干膏中异秦皮啶的质量分数最高。结论微滤是草珊瑚浸膏膜分离纯化新工艺中较为理想的预处理方法。Objective To investigate the different pretreatments of Caoshanhu extract and their effects on the downstream process, membrane separation. Methods Based on the index related to isofraxidin, the different pretreatment methods of Caoshanhu extract were evaluated and their effects on membrane separation downstream were analyzed by the comparison of different pretreatments and further orthogonal test of ZTC1＋1Ⅱ, chitosan, and KA1 （SO4）2·12H2O. Results After the pretreatment of microfiltration, both the best membrane flux and the highest percentage of isofraxidin filtered through the membrane were obtained and the time used was the least, and the ratio of isofraxidin to insoluble substances was tiptop in all pretreatment methods in comparison to other methods, such as ZTC1＋1 Ⅱ, chitosan, and KA1（SO4）2·12H2O methods. Conclusion Microfiltration is a better pretreatment method in preparation of Caoshanhu extract.

关 键 词：草珊瑚浸膏 预处理 膜分离 异秦皮啶 

分 类 号：R284.2[医药卫生—中药学] R286.02[医药卫生—中医学]