带状疱疹急性期应用卡维地洛预防疱疹后神经痛的研究  

Study on the prevention of PHN by carvediloladministrated in acute herpes-zoster.

作　　者：谢珺田[1] 傅志俭[1] 王建峰[1] 张晓[1] 

机构地区：[1]山东省立医院,山东济南250021

出　　处：《山东医药》2006年第2期18-19,共2页Shandong Medical Journal

基　　金：山东省医药卫生科研项目(2003HW109)

摘　　要：目的探讨带状疱疹急性期应用卡维地洛预防疱疹后神经痛(PHN)的可行性及效果。方法将60例急性期带状疱疹患者随机分为干预组和对照组,每组30例。两组均给予常规治疗14d,包括抗病毒、营养神经、消炎止痛和神经安定药物;干预组在此基础上给予卡维地洛10m g,1次/d,共14d。分别于治疗前及治疗后2、4、8、12周进行疼痛评估。观测指标包括神经病理性疼痛评分(NPS)、视觉模拟评分(VA S)、痛觉过敏、触诱发痛、痛觉总和及感觉后遗现象。结果干预组VA S、NPS低于对照组(P分别<0.05、0.01),NPS中不适感、瘙痒和烧灼感的主诉明显少于对照组(P分别<0.01、0.01、0.05)。对照组PHN的发生率为26.6%(8/30),干预组为3.33%(1/30),P<0.05。结论带状疱疹急性期应用卡维地洛可降低PHN的发生率,并能缓解急性期症状。Objective To estimate the feasibility of preventing PHN by using carvedilol in acute phase of zoster. Methods： 60 cases of zoster in acute phase were didvided ramdomly into control group and carvedilol group with 30 cases in each group. Both groups were treated with routine methods and carvedilol group was given carvedilol additionally. NPS, VAS, summation,after sensation, hyperalgia and allodynia were observed. Results; VAS, NPS and occurence rate of PHN in carvedilol group were lower than that in control group （P〈 0. 05, 〈0. 01, 〈0. 05）. Conclusions： Use of carvedilol in acute phase of zoster may decrease the occurrence rate of PHN and remit symptom.

关 键 词：带状疱疹 后遣症 疼痛 卡维地洛 

分 类 号：R752.1[医药卫生—皮肤病学与性病学]